Matches in SemOpenAlex for { <https://semopenalex.org/work/W9702650> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W9702650 abstract "Alzheimer's disease (AD) is the commonest cause of dementia in ageing. Over the past decade many studies have focused on neuroinflammation as a harmful feature of AD, with the implication that antiinflammatory therapy may be beneficial. More recently, immunization with amyloid ?-peptide (A?) has been proposed as a novel treatment for AD. Experimental models have shown that A? accumulation in the brain, a key feature of the disease, can be reversed by immunotherapy mediated, at least in part, by phagocytosis by microglia, the cerebral macrophage. We are co-ordinating collaborative clinical and neuropathological follow-up of the patients who where in the original trial of A? immunotherapy runs by Elan Pharmaceuticals which started in 2000. Immunohistochemical study of the immunized AD cases examined to date (n=8) shows that the A? plaque removal varies from patchy to almost complete clearance. Doublelabel confocal microscopy was performed with antibody to A? and either CD68 (PG-M1; a protein located on microglial lysosomes which therefore reflects phagocytic activity) or HLA-DR (CR3/43; MHC class II). This showed that plaque removal is associated with the presence of A? within the lysosomes of activated microglia, indicating that the A? has been phagocytosed. In cases of unimmunized AD there was microglial activation, but very little evidence of A? phagocytosis. These observations are in contrast to previous evidence that microglial activation in neurodegenerative disorders is only harmful, and suggest that microglial activation represents a two-edged sword with both harmful and potentially beneficial effects" @default.
- W9702650 created "2016-06-24" @default.
- W9702650 creator A5008325892 @default.
- W9702650 creator A5054761749 @default.
- W9702650 creator A5064532444 @default.
- W9702650 creator A5065736290 @default.
- W9702650 creator A5070103983 @default.
- W9702650 creator A5082712367 @default.
- W9702650 date "2006-09-01" @default.
- W9702650 modified "2023-09-28" @default.
- W9702650 title "Neuroinflammation and Alzheimer's disease: implications of Abeta immunotherapy" @default.
- W9702650 hasPublicationYear "2006" @default.
- W9702650 type Work @default.
- W9702650 sameAs 9702650 @default.
- W9702650 citedByCount "0" @default.
- W9702650 crossrefType "journal-article" @default.
- W9702650 hasAuthorship W9702650A5008325892 @default.
- W9702650 hasAuthorship W9702650A5054761749 @default.
- W9702650 hasAuthorship W9702650A5064532444 @default.
- W9702650 hasAuthorship W9702650A5065736290 @default.
- W9702650 hasAuthorship W9702650A5070103983 @default.
- W9702650 hasAuthorship W9702650A5082712367 @default.
- W9702650 hasBestOaLocation W97026501 @default.
- W9702650 hasConcept C142724271 @default.
- W9702650 hasConcept C160448771 @default.
- W9702650 hasConcept C203014093 @default.
- W9702650 hasConcept C204232928 @default.
- W9702650 hasConcept C2776460901 @default.
- W9702650 hasConcept C2776914184 @default.
- W9702650 hasConcept C2777633098 @default.
- W9702650 hasConcept C2777701055 @default.
- W9702650 hasConcept C2779134260 @default.
- W9702650 hasConcept C2779483572 @default.
- W9702650 hasConcept C2779830541 @default.
- W9702650 hasConcept C502032728 @default.
- W9702650 hasConcept C71924100 @default.
- W9702650 hasConcept C87753298 @default.
- W9702650 hasConcept C8891405 @default.
- W9702650 hasConceptScore W9702650C142724271 @default.
- W9702650 hasConceptScore W9702650C160448771 @default.
- W9702650 hasConceptScore W9702650C203014093 @default.
- W9702650 hasConceptScore W9702650C204232928 @default.
- W9702650 hasConceptScore W9702650C2776460901 @default.
- W9702650 hasConceptScore W9702650C2776914184 @default.
- W9702650 hasConceptScore W9702650C2777633098 @default.
- W9702650 hasConceptScore W9702650C2777701055 @default.
- W9702650 hasConceptScore W9702650C2779134260 @default.
- W9702650 hasConceptScore W9702650C2779483572 @default.
- W9702650 hasConceptScore W9702650C2779830541 @default.
- W9702650 hasConceptScore W9702650C502032728 @default.
- W9702650 hasConceptScore W9702650C71924100 @default.
- W9702650 hasConceptScore W9702650C87753298 @default.
- W9702650 hasConceptScore W9702650C8891405 @default.
- W9702650 hasLocation W97026501 @default.
- W9702650 hasLocation W97026502 @default.
- W9702650 hasOpenAccess W9702650 @default.
- W9702650 hasPrimaryLocation W97026501 @default.
- W9702650 hasRelatedWork W1565096249 @default.
- W9702650 hasRelatedWork W1850100528 @default.
- W9702650 hasRelatedWork W1968211534 @default.
- W9702650 hasRelatedWork W1994326835 @default.
- W9702650 hasRelatedWork W1995357368 @default.
- W9702650 hasRelatedWork W2002352560 @default.
- W9702650 hasRelatedWork W2025541814 @default.
- W9702650 hasRelatedWork W2032764085 @default.
- W9702650 hasRelatedWork W2039298559 @default.
- W9702650 hasRelatedWork W2460405435 @default.
- W9702650 hasRelatedWork W2533073311 @default.
- W9702650 hasRelatedWork W2651436174 @default.
- W9702650 hasRelatedWork W2800869030 @default.
- W9702650 hasRelatedWork W2896692455 @default.
- W9702650 hasRelatedWork W2954290075 @default.
- W9702650 hasRelatedWork W2964607043 @default.
- W9702650 hasRelatedWork W2982165025 @default.
- W9702650 hasRelatedWork W3016434140 @default.
- W9702650 hasRelatedWork W3137983422 @default.
- W9702650 hasRelatedWork W3211570902 @default.
- W9702650 isParatext "false" @default.
- W9702650 isRetracted "false" @default.
- W9702650 magId "9702650" @default.
- W9702650 workType "article" @default.