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- W970402543 abstract "This chapter reveals the Wnt/β-catenin signaling pathway and describes its regulation as it pertains to bone. The major players in the Wnt/β-catenin signaling pathway in bone are: the cell surface coreceptors Lrp5/6 and frizzled; the intracellular proteins Disheveled (Dsh), glycogen synthase kinase-3 β (GSK-3 β), Axin, and β-catenin; and the nuclear transcription factors that bind β-catenin and regulate gene expression. In addition, there are a number of other extracellular and intracellular proteins involved in regulation of this pathway that serve to modify the functionality of one of these key proteins. Wnt/β-catenin signaling regulates osteogenesis through multiple mechanisms. Wnt/β-catenin signaling has been shown to promote osteogenesis by direct stimulation of Runx2 gene expression. Activation of Wnt/β-catenin signaling also promotes further osteoblast cell proliferation and mineralization activity, reduces osteoblast apoptosis, and can suppress osteoclast differentiation induced by osteoblasts. However, the Wnt/β-catenin signaling pathway is not the only pathway that is known to be important in the regulation of bone cell activities. GSK-3 β is the critical intracellular enzyme controlling β-catenin levels. Therefore any pathway that can regulate GSK-3 β activity has the potential to interact with the Wnt/β-catenin signaling pathway independent of the coreceptors and any modulators that function at that level. The Wnt signaling pathway is being studies as a target for anabolic therapy in. bone." @default.
- W970402543 created "2016-06-24" @default.
- W970402543 creator A5060693982 @default.
- W970402543 date "2008-01-01" @default.
- W970402543 modified "2023-09-26" @default.
- W970402543 title "Wnt Signaling and Bone" @default.
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