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- W970605066 endingPage "626" @default.
- W970605066 startingPage "616" @default.
- W970605066 abstract "Rat maternal behavior is a complex social behavior. Many clinically used antipsychotic drugs, including the typical drug haloperidol and the atypical drugs clozapine, risperidone, olanzapine, quetiapine, aripiprazole, and amisulpride, disrupt active maternal responses (e.g. pup retrieval, pup licking, and nest building) to various extents. In this review, I present a summary of recent studies on the behavioral effects and neurobiological mechanisms of antipsychotic action on maternal behavior in rats. I argue that antipsychotic drugs at clinically relevant doses disrupt active maternal responses primarily by suppressing maternal motivation. Atypical drug-induced sedation also contributes to their disruptive effects, especially that on pup nursing. Among many potential receptor mechanisms, dopamine D2 receptors and serotonin 5-HT2A/2C receptors are shown to be critically involved in the mediation of the maternal disruptive effects of antipsychotic drugs, with D2 receptors contributing more to typical antipsychotic-induced disruptions, whereas 5-HT2A/2C receptors contributing more to atypical drug-induced disruptions. The nucleus accumbens shell-related reward circuitry is an essential neural network in the mediation of the behavioral effects of antipsychotic drugs on maternal behavior. This research not only helps understand the extent and mechanisms of impact of antipsychotic medications on human maternal care, but is also important for enhancing our understanding of the neurochemical basis of maternal behavior. It is also valuable for understanding the complete spectrum of therapeutic effects and side-effects of antipsychotic treatment. This knowledge may facilitate the development of effective intervening strategies to help patients coping with such undesirable effects." @default.
- W970605066 created "2016-06-24" @default.
- W970605066 creator A5021384155 @default.
- W970605066 date "2015-09-01" @default.
- W970605066 modified "2023-09-26" @default.
- W970605066 title "Antipsychotic drugs on maternal behavior in rats" @default.
- W970605066 cites W153750880 @default.
- W970605066 cites W1576900940 @default.
- W970605066 cites W1963724961 @default.
- W970605066 cites W1965065820 @default.
- W970605066 cites W1965606923 @default.
- W970605066 cites W1968490092 @default.
- W970605066 cites W1968942082 @default.
- W970605066 cites W1970399699 @default.
- W970605066 cites W1971203766 @default.
- W970605066 cites W1972498750 @default.
- W970605066 cites W1973786220 @default.
- W970605066 cites W1975845756 @default.
- W970605066 cites W1978673730 @default.
- W970605066 cites W1983723736 @default.
- W970605066 cites W1987575722 @default.
- W970605066 cites W1990067444 @default.
- W970605066 cites W1993631201 @default.
- W970605066 cites W1993855542 @default.
- W970605066 cites W1996187894 @default.
- W970605066 cites W1997494395 @default.
- W970605066 cites W1999545307 @default.
- W970605066 cites W2000636120 @default.
- W970605066 cites W2002884880 @default.
- W970605066 cites W2003463662 @default.
- W970605066 cites W2005096597 @default.
- W970605066 cites W2007730845 @default.
- W970605066 cites W2009752277 @default.
- W970605066 cites W2011374337 @default.
- W970605066 cites W2012103900 @default.
- W970605066 cites W2013333057 @default.
- W970605066 cites W2018742347 @default.
- W970605066 cites W2019512157 @default.
- W970605066 cites W2029371096 @default.
- W970605066 cites W2030029954 @default.
- W970605066 cites W2030801264 @default.
- W970605066 cites W2036377884 @default.
- W970605066 cites W2041495183 @default.
- W970605066 cites W2043469614 @default.
- W970605066 cites W2044368718 @default.
- W970605066 cites W2044455782 @default.
- W970605066 cites W2046664137 @default.
- W970605066 cites W2047838561 @default.
- W970605066 cites W2048560535 @default.
- W970605066 cites W2048905830 @default.
- W970605066 cites W2050604710 @default.
- W970605066 cites W2056021443 @default.
- W970605066 cites W2062610641 @default.
- W970605066 cites W2062837515 @default.
- W970605066 cites W2065618917 @default.
- W970605066 cites W2066848136 @default.
- W970605066 cites W2068369227 @default.
- W970605066 cites W2074937887 @default.
- W970605066 cites W2077786958 @default.
- W970605066 cites W2081041495 @default.
- W970605066 cites W2081963616 @default.
- W970605066 cites W2083163486 @default.
- W970605066 cites W2087158792 @default.
- W970605066 cites W2092416470 @default.
- W970605066 cites W2092666379 @default.
- W970605066 cites W2092670749 @default.
- W970605066 cites W2095213614 @default.
- W970605066 cites W2096165115 @default.
- W970605066 cites W2099576957 @default.
- W970605066 cites W2103833972 @default.
- W970605066 cites W2109481947 @default.
- W970605066 cites W2109686634 @default.
- W970605066 cites W2110091980 @default.
- W970605066 cites W2113544707 @default.
- W970605066 cites W2125176394 @default.
- W970605066 cites W2128686447 @default.
- W970605066 cites W2128717592 @default.
- W970605066 cites W2129321699 @default.
- W970605066 cites W2130486396 @default.
- W970605066 cites W2132980997 @default.
- W970605066 cites W2135162974 @default.
- W970605066 cites W2159155203 @default.
- W970605066 cites W2159992706 @default.
- W970605066 cites W2160695817 @default.
- W970605066 cites W2162144610 @default.
- W970605066 cites W2168254898 @default.
- W970605066 cites W2297783225 @default.
- W970605066 cites W2392506815 @default.
- W970605066 cites W4230831276 @default.
- W970605066 cites W4231069749 @default.
- W970605066 cites W4238512264 @default.
- W970605066 cites W4239133254 @default.
- W970605066 cites W4240209796 @default.
- W970605066 cites W4247951875 @default.
- W970605066 cites W50693228 @default.
- W970605066 cites W782321475 @default.
- W970605066 doi "https://doi.org/10.1097/fbp.0000000000000168" @default.
- W970605066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4520249" @default.