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- W97061837 abstract "Insulin acts in the Arcuate Nucleus (ArcN) to increase lumbar sympathetic nerve activity (LSNA) and LSNA baroreflex gain (BRG) via a pathway that includes the hypothalamic paraventricular nucleus (PVN). Two ArcN neuronal types project to PVN: melanocortin (MC) and Neuropeptide Y (NPY). Recent data implicates MC in the sympathoexcitatory effect of insulin, but whether NPY also contributes is unknown. To test this hypothesis, we determined if inhibition of PVN NPY type 1 receptors (Y1x) reduces the effect of ArcN insulin to increase LSNA and LSNA BRG. In chloralose-anesthetized female rats, bilateral microinjection (60nL) of insulin in ArcN (n=3; 0.06nU) increased (P<0.05) LSNA (132±7%) and LSNA BRG (3.9±0.4 to 6.9±0.6 %/mmHg). PVN Y1x (n=5; BIBO3304; 60pmol) also increased (P<0.05) LSNA (161±14%) and LSNA BRG (3.5±0.5 to 5.4±0.9 %/mmHg), indicating endogenous NPY inhibits LSNA. ArcN insulin and PVN Y1x given together (n=5) did not increase LSNA (155±12%; P<0.05) or LSNA BRG (3.4±0.5 to 6.0±1.2 %/mmHg; P<0.05) more than either alone, suggesting a converging pathway. Conversely, microinjection of NPY in PVN (n=3; 6pmol) decreased (P<0.05) LSNA (68±14%) and LSNA BRG (5.8±0.6 to 3.4±0.4 %/mmHg), and PVN NPY and ArcN insulin together (n=3) produced similar decreases in LSNA (63±15%; P<0.05) and LSNA BRG (4.9±1.3 to 2.9±0.9 %/mmHg; P<0.05). Thus, PVN NPY blocked the effect of ArcN insulin. These data support the hypothesis that ArcN insulin increases LSNA and LSNA BRG in part via inhibition of PVN-projecting NPY neurons. Support: HL088552." @default.
- W97061837 created "2016-06-24" @default.
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- W97061837 date "2012-04-01" @default.
- W97061837 modified "2023-09-23" @default.
- W97061837 title "Does PVN Neuropeptide Y contribute to the sympathoexcitatory effect of insulin in the arcuate nucleus?" @default.
- W97061837 doi "https://doi.org/10.1096/fasebj.26.1_supplement.893.9" @default.
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