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- W97064410 abstract "A wide variety of clinical syndromes can manifest cognitive or memory dysfunction. These include head trauma, cerebrovascular accidents, convulsive disorders, nutritional deficits, drug-associated toxicity, etc. Although collectively these entities contribute significantly to the overall amalgamation of known memory disorders, by far the primary disease entity targeted by pharmaceutical research is Alzheimer’s disease (AD). AD, which represents the most common form of dementia among individuals over 65 years of age, is now the third most expensive health care problem in the U.S. exceeded only by cancer and cardiovascular disease. It currently affects approximately 4 million Americans and imposes an annual economic burden estimated at between $80 and $100 billion. This devastating degenerative condition also inflicts an enormous emotional toll on patients, family members, and caregivers. As the geriatric population inexorably increases, the numbers of AD patients may increase to epidemic numbers (i.e., in excess of 9 million) by the middle of the twenty first century." @default.
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- W97064410 date "2004-01-01" @default.
- W97064410 modified "2023-09-23" @default.
- W97064410 title "Drugs with multiple CNS targets" @default.
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- W97064410 doi "https://doi.org/10.1007/978-3-0348-7867-8_11" @default.
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