Matches in SemOpenAlex for { <https://semopenalex.org/work/W97083158> ?p ?o ?g. }
- W97083158 endingPage "154" @default.
- W97083158 startingPage "143" @default.
- W97083158 abstract "Bone marrow stromal cells make up the microenvironment for hematopoiesis. The prototype for stem cell and lineages is that of the hematopoietic stem cell (HSC), as demonstrated by clonal analysis. The fate of the HSC is determined largely by the microenvironment (niche) provided by the mesenchymal stem cells (MSC). MSCs give rise to cells constituting the hematopoietic microenvironnement—i.e., stromal cells, endothelial cells, vascular smooth muscle cells (VSMCs), adipocytes, and osteoblasts—but also to other cell types—i.e., chondrocytes; sarcomeric muscle; and, in certain reports, neuroectoderm or endodermal cells. Transdifferentiation of MSC progeny seems more likely than in other cell lineages, and stromal cells from the different hematopoietic sites (bone marrow, fetal liver, aorta-gonad-mesonephros region) express a variety of mesenchymal cell–type markers, including markers for VSMCs, adipocytes, and osteoblasts. Stromal cells act through a number of mediators, cytokines, adhesion molecules, peptides, hormones, and other molecules such as wnts and eicosanoids. Cytokines and chemokines include the colony-stimulating factors, interleukin-6 (IL-6), leukemia inhibitory factor, IL-1, IL-7, IL-8, stem cell factor, flt3 ligand, hepatocyte growth factor, thrombopoietin, insulin-like growth factor1, transforming growth factor-3 TGF-β, -β-interferon-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), and stromal-derived factor-1 (see Table 2 in this chapter). IL-1 is a major inducer of the production of the other cytokines. TGF-βis the most potent inhibitor of hematopoiesis. It induces expression of inhibitory chemokines, such as MCP-1 and IP-10, and decreases expression of stromal adhesion molecules. Extracellular matrix collagens, laminins, and fibronectins each appear to have a role in hematopoiesis through binding to a number of cell adhesion molecules (see Table 3 of this chapter). This indicates a highly controlled, multifactorial, and redundant regulation of hematopoiesis by mesenchymal stromal cells." @default.
- W97083158 created "2016-06-24" @default.
- W97083158 creator A5069746882 @default.
- W97083158 date "2004-01-01" @default.
- W97083158 modified "2023-09-23" @default.
- W97083158 title "Stromal Support of Hematopoiesis" @default.
- W97083158 cites W126539919 @default.
- W97083158 cites W1272522950 @default.
- W97083158 cites W128119376 @default.
- W97083158 cites W129232635 @default.
- W97083158 cites W129269179 @default.
- W97083158 cites W1490349467 @default.
- W97083158 cites W1494887369 @default.
- W97083158 cites W1505671001 @default.
- W97083158 cites W151805421 @default.
- W97083158 cites W1530645450 @default.
- W97083158 cites W1537928632 @default.
- W97083158 cites W1538762819 @default.
- W97083158 cites W1555330200 @default.
- W97083158 cites W1564415256 @default.
- W97083158 cites W1592800848 @default.
- W97083158 cites W1599481344 @default.
- W97083158 cites W1600272283 @default.
- W97083158 cites W1623949947 @default.
- W97083158 cites W1807807041 @default.
- W97083158 cites W183596108 @default.
- W97083158 cites W1861117943 @default.
- W97083158 cites W1861988602 @default.
- W97083158 cites W1876681729 @default.
- W97083158 cites W1890881866 @default.
- W97083158 cites W1911887288 @default.
- W97083158 cites W191322410 @default.
- W97083158 cites W1918057567 @default.
- W97083158 cites W1924777753 @default.
- W97083158 cites W194792082 @default.
- W97083158 cites W1965953554 @default.
- W97083158 cites W1968541478 @default.
- W97083158 cites W1970590929 @default.
- W97083158 cites W1972456134 @default.
- W97083158 cites W1974262404 @default.
- W97083158 cites W1975786417 @default.
- W97083158 cites W1977262486 @default.
- W97083158 cites W1980654055 @default.
- W97083158 cites W1980871625 @default.
- W97083158 cites W1981043866 @default.
- W97083158 cites W1981211571 @default.
- W97083158 cites W1982086172 @default.
- W97083158 cites W1991894039 @default.
- W97083158 cites W1992407135 @default.
- W97083158 cites W1993235020 @default.
- W97083158 cites W1993789974 @default.
- W97083158 cites W1996315201 @default.
- W97083158 cites W1997538514 @default.
- W97083158 cites W2000927180 @default.
- W97083158 cites W2006822999 @default.
- W97083158 cites W2018934530 @default.
- W97083158 cites W2019480285 @default.
- W97083158 cites W2024582190 @default.
- W97083158 cites W2027538325 @default.
- W97083158 cites W2030771547 @default.
- W97083158 cites W2036452348 @default.
- W97083158 cites W2039269834 @default.
- W97083158 cites W2040475603 @default.
- W97083158 cites W2042318797 @default.
- W97083158 cites W2043129312 @default.
- W97083158 cites W2044455394 @default.
- W97083158 cites W2050996646 @default.
- W97083158 cites W2052733254 @default.
- W97083158 cites W2057637267 @default.
- W97083158 cites W2058809631 @default.
- W97083158 cites W2059057508 @default.
- W97083158 cites W2063786558 @default.
- W97083158 cites W2065052563 @default.
- W97083158 cites W2067190714 @default.
- W97083158 cites W2068102253 @default.
- W97083158 cites W2070669446 @default.
- W97083158 cites W2072096825 @default.
- W97083158 cites W2075971846 @default.
- W97083158 cites W2077111687 @default.
- W97083158 cites W2079698917 @default.
- W97083158 cites W2084436684 @default.
- W97083158 cites W2085726512 @default.
- W97083158 cites W2086221434 @default.
- W97083158 cites W2086793358 @default.
- W97083158 cites W2090121937 @default.
- W97083158 cites W2090529961 @default.
- W97083158 cites W2093681591 @default.
- W97083158 cites W2095257528 @default.
- W97083158 cites W2098734814 @default.
- W97083158 cites W2103546044 @default.
- W97083158 cites W2106008201 @default.
- W97083158 cites W2106811339 @default.
- W97083158 cites W2110819175 @default.
- W97083158 cites W2113551580 @default.
- W97083158 cites W2118024162 @default.
- W97083158 cites W2119537673 @default.
- W97083158 cites W2119695863 @default.
- W97083158 cites W2129746041 @default.