Matches in SemOpenAlex for { <https://semopenalex.org/work/W970849724> ?p ?o ?g. }
- W970849724 endingPage "8" @default.
- W970849724 startingPage "5121" @default.
- W970849724 abstract "3,3'-Diindolylmethane (DIM) is a natural component of cruciferous plants. Previous studies have shown that DIM has multiple physiological effects including anti-angiogenic, anti-inflammatory and anti-cancer effect. However, little is known about the role of DIM on myofibroblast differentiation and extracellular matrix (ECM) production. This study investigated the effect of DIM on myofibroblast differentiation and ECM production in neonatal rat cardiac fibroblasts induced by transforming growth factor β1 (TGF-β1). We found that DIM blunted TGF-β1 induced conversion of cardiac fibroblast into myofibroblast, and reduced the mRNA and protein expressions of α-smooth muscle actin (α-SMA). Furthermore, DIM also significantly decreased the mRNA expression of fibrosis markers (Collagen I, Collagen III, connective tissue growth factor (CTGF) in neonatal rat cardiac fibroblasts induced by TGF-β1. DIM attenuated the phosphorylation AKT and glycogen synthase kinase-3β (GSK-3β) induced by TGF-β1. Our results showed that DIM was a potential drug to attenuate myofibroblast differentiation and excessive ECM production induced by TGF-β1 through down-regulated AKT/GSK-3β signaling pathways." @default.
- W970849724 created "2016-06-24" @default.
- W970849724 creator A5011540763 @default.
- W970849724 creator A5027255522 @default.
- W970849724 creator A5043958091 @default.
- W970849724 creator A5056140695 @default.
- W970849724 creator A5056611359 @default.
- W970849724 creator A5059015054 @default.
- W970849724 creator A5073005690 @default.
- W970849724 creator A5077889525 @default.
- W970849724 creator A5078874926 @default.
- W970849724 date "2015-01-01" @default.
- W970849724 modified "2023-09-23" @default.
- W970849724 title "DIM attenuates TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts." @default.
- W970849724 cites W1862724536 @default.
- W970849724 cites W1948740966 @default.
- W970849724 cites W1966251109 @default.
- W970849724 cites W1969590456 @default.
- W970849724 cites W1989610794 @default.
- W970849724 cites W1993929076 @default.
- W970849724 cites W1998550705 @default.
- W970849724 cites W1999187094 @default.
- W970849724 cites W2001754191 @default.
- W970849724 cites W2007412101 @default.
- W970849724 cites W2007574124 @default.
- W970849724 cites W2027952618 @default.
- W970849724 cites W2051975676 @default.
- W970849724 cites W2052472486 @default.
- W970849724 cites W2057386289 @default.
- W970849724 cites W2061411700 @default.
- W970849724 cites W2079131177 @default.
- W970849724 cites W2085840119 @default.
- W970849724 cites W2086670943 @default.
- W970849724 cites W2088222747 @default.
- W970849724 cites W2101514652 @default.
- W970849724 cites W2104483699 @default.
- W970849724 cites W2113024711 @default.
- W970849724 cites W2136981364 @default.
- W970849724 cites W2150428021 @default.
- W970849724 cites W2150621532 @default.
- W970849724 cites W2157686687 @default.
- W970849724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4503079" @default.
- W970849724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26191207" @default.
- W970849724 hasPublicationYear "2015" @default.
- W970849724 type Work @default.
- W970849724 sameAs 970849724 @default.
- W970849724 citedByCount "7" @default.
- W970849724 countsByYear W9708497242015 @default.
- W970849724 countsByYear W9708497242017 @default.
- W970849724 countsByYear W9708497242018 @default.
- W970849724 countsByYear W9708497242019 @default.
- W970849724 countsByYear W9708497242022 @default.
- W970849724 crossrefType "journal-article" @default.
- W970849724 hasAuthorship W970849724A5011540763 @default.
- W970849724 hasAuthorship W970849724A5027255522 @default.
- W970849724 hasAuthorship W970849724A5043958091 @default.
- W970849724 hasAuthorship W970849724A5056140695 @default.
- W970849724 hasAuthorship W970849724A5056611359 @default.
- W970849724 hasAuthorship W970849724A5059015054 @default.
- W970849724 hasAuthorship W970849724A5073005690 @default.
- W970849724 hasAuthorship W970849724A5077889525 @default.
- W970849724 hasAuthorship W970849724A5078874926 @default.
- W970849724 hasConcept C104317684 @default.
- W970849724 hasConcept C118131993 @default.
- W970849724 hasConcept C126322002 @default.
- W970849724 hasConcept C134018914 @default.
- W970849724 hasConcept C142724271 @default.
- W970849724 hasConcept C148738053 @default.
- W970849724 hasConcept C170493617 @default.
- W970849724 hasConcept C182996813 @default.
- W970849724 hasConcept C185592680 @default.
- W970849724 hasConcept C189165786 @default.
- W970849724 hasConcept C207865475 @default.
- W970849724 hasConcept C2775960820 @default.
- W970849724 hasConcept C2777420927 @default.
- W970849724 hasConcept C2778229498 @default.
- W970849724 hasConcept C2780381497 @default.
- W970849724 hasConcept C2780559512 @default.
- W970849724 hasConcept C2780631158 @default.
- W970849724 hasConcept C502942594 @default.
- W970849724 hasConcept C518705261 @default.
- W970849724 hasConcept C54355233 @default.
- W970849724 hasConcept C55493867 @default.
- W970849724 hasConcept C62478195 @default.
- W970849724 hasConcept C71924100 @default.
- W970849724 hasConcept C75217442 @default.
- W970849724 hasConcept C81885089 @default.
- W970849724 hasConcept C86803240 @default.
- W970849724 hasConcept C95444343 @default.
- W970849724 hasConceptScore W970849724C104317684 @default.
- W970849724 hasConceptScore W970849724C118131993 @default.
- W970849724 hasConceptScore W970849724C126322002 @default.
- W970849724 hasConceptScore W970849724C134018914 @default.
- W970849724 hasConceptScore W970849724C142724271 @default.
- W970849724 hasConceptScore W970849724C148738053 @default.
- W970849724 hasConceptScore W970849724C170493617 @default.
- W970849724 hasConceptScore W970849724C182996813 @default.
- W970849724 hasConceptScore W970849724C185592680 @default.