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- W970965416 abstract "Objective To evaluate the effects of transforming growth factor β1 (TGF β1) autocrine blockage on proliferation activity and drug sensitivity of osteosarcoma.Methods Northern blot, MTT determination, and 3H thymidine incorporation were used to investigate the effects of antisense TGF β1 gene on osteosarcoma.Results The proliferation of osteosarcoma cells transfected by antisense TGF β1 gene was suppressed markedly, and adriamycin sensitivity was significantly increased.Conclusion Blockage ofosteosarcoma cells TGF β1 autocrine loop inhibits cell proliferation and enhances chemotherapy sensitivity." @default.
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- W970965416 date "2004-01-01" @default.
- W970965416 modified "2023-09-23" @default.
- W970965416 title "EFFECTS OF TGF β1 AUTOCRINE BLOCKAGE ON OSTEOSARCOMA CELLS" @default.
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