FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W97096688> ?p ?o ?g. }

• W97096688 endingPage "35" @default.
• W97096688 startingPage "27" @default.
• W97096688 abstract "Objective To describe the immunological and virological outcome, and the factors associated to discontinuation in patients switching to a regimen containing efavirenz (EFV), nevirapine (NVP) or abacavir (ABC) after long-term viral suppression under protease inhibitor-including HAART. Design Observational study at three outpatient clinics for HIV care in Italy. Methods Patients with HIV RNA <80 copies/ml and CD4 >200 cells/ml for at least 6 months on a protease inhibitor-containing treatment who switched to NVP, EFV or ABC were included in the study. End-points were immunological failure, virological failure and discontinuation due to toxicity. Survival analyses were performed to find out any independent variables predictive of reaching the end-points. Results 177 patients were enrolled; 85 started EFV, 54 NVP and 38 ABC as part of the simplification regimen. 16/159 patients experienced immunological failure: the variables associated to CD4 count decrease were HIV RNA set point value (HR 2.32 for each log 10 copies more, P=0.040) and intolerance/toxicity as reason for simplification (HR 3.96, P=0.05). 13/151 subjects showed virological failure; an AIDS diagnosis (HR 6.04, P=0.021) and the use of NVP (HR 7.98, P=0.027) were associated to a worse virological outcome, while patients naive before HAART showed a lower risk of failure (HR 0.008, P=0.007). 16/177 patients discontinued simplification regimen due to toxicity; longer HAART duration before switch was associated to risk reduction (HR 0.92, P=0.004). Conclusions Simplification is safe and effective, but it should be offered to patients with shorter treatment duration, and in good clinical and immunovirological conditions." @default.
• W97096688 created "2016-06-24" @default.
• W97096688 creator A5011093773 @default.
• W97096688 creator A5014263659 @default.
• W97096688 creator A5014801178 @default.
• W97096688 creator A5023946865 @default.
• W97096688 creator A5028821098 @default.
• W97096688 creator A5029651138 @default.
• W97096688 creator A5036157453 @default.
• W97096688 creator A5040869978 @default.
• W97096688 creator A5044055346 @default.
• W97096688 creator A5044411998 @default.
• W97096688 creator A5067597194 @default.
• W97096688 creator A5068011395 @default.
• W97096688 creator A5074671177 @default.
• W97096688 creator A5078701955 @default.
• W97096688 creator A5082122622 @default.
• W97096688 date "2003-01-01" @default.
• W97096688 modified "2023-10-11" @default.
• W97096688 title "Simplification of Protease Inhibitor-Containing Regimens with Efavirenz, Nevirapine or Abacavir: Safety and Efficacy Outcomes" @default.
• W97096688 cites W1497870368 @default.
• W97096688 cites W1970713740 @default.
• W97096688 cites W1978444406 @default.
• W97096688 cites W1979721624 @default.
• W97096688 cites W1985646480 @default.
• W97096688 cites W1996715778 @default.
• W97096688 cites W2031037912 @default.
• W97096688 cites W2054385676 @default.
• W97096688 cites W2056118379 @default.
• W97096688 cites W2062515126 @default.
• W97096688 cites W2076459993 @default.
• W97096688 cites W2090980433 @default.
• W97096688 cites W2092398687 @default.
• W97096688 cites W2109536957 @default.
• W97096688 cites W2113643689 @default.
• W97096688 cites W2126311717 @default.
• W97096688 cites W2129710521 @default.
• W97096688 cites W2133315239 @default.
• W97096688 cites W2151420123 @default.
• W97096688 cites W2160676835 @default.
• W97096688 cites W2313623892 @default.
• W97096688 cites W2318289184 @default.
• W97096688 cites W2321852728 @default.
• W97096688 cites W2324473093 @default.
• W97096688 cites W2337376130 @default.
• W97096688 cites W4250396005 @default.
• W97096688 doi "https://doi.org/10.1177/135965350300800104" @default.
• W97096688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12713061" @default.
• W97096688 hasPublicationYear "2003" @default.
• W97096688 type Work @default.
• W97096688 sameAs 97096688 @default.
• W97096688 citedByCount "11" @default.
• W97096688 countsByYear W970966882013 @default.
• W97096688 countsByYear W970966882015 @default.
• W97096688 crossrefType "journal-article" @default.
• W97096688 hasAuthorship W97096688A5011093773 @default.
• W97096688 hasAuthorship W97096688A5014263659 @default.
• W97096688 hasAuthorship W97096688A5014801178 @default.
• W97096688 hasAuthorship W97096688A5023946865 @default.
• W97096688 hasAuthorship W97096688A5028821098 @default.
• W97096688 hasAuthorship W97096688A5029651138 @default.
• W97096688 hasAuthorship W97096688A5036157453 @default.
• W97096688 hasAuthorship W97096688A5040869978 @default.
• W97096688 hasAuthorship W97096688A5044055346 @default.
• W97096688 hasAuthorship W97096688A5044411998 @default.
• W97096688 hasAuthorship W97096688A5067597194 @default.
• W97096688 hasAuthorship W97096688A5068011395 @default.
• W97096688 hasAuthorship W97096688A5074671177 @default.
• W97096688 hasAuthorship W97096688A5078701955 @default.
• W97096688 hasAuthorship W97096688A5082122622 @default.
• W97096688 hasBestOaLocation W970966881 @default.
• W97096688 hasConcept C126322002 @default.
• W97096688 hasConcept C142462285 @default.
• W97096688 hasConcept C203014093 @default.
• W97096688 hasConcept C2778715236 @default.
• W97096688 hasConcept C2779130552 @default.
• W97096688 hasConcept C2779298103 @default.
• W97096688 hasConcept C2779465607 @default.
• W97096688 hasConcept C2781143361 @default.
• W97096688 hasConcept C2781413609 @default.
• W97096688 hasConcept C2781432083 @default.
• W97096688 hasConcept C29730261 @default.
• W97096688 hasConcept C2993143319 @default.
• W97096688 hasConcept C3013748606 @default.
• W97096688 hasConcept C71924100 @default.
• W97096688 hasConcept C90924648 @default.
• W97096688 hasConceptScore W97096688C126322002 @default.
• W97096688 hasConceptScore W97096688C142462285 @default.
• W97096688 hasConceptScore W97096688C203014093 @default.
• W97096688 hasConceptScore W97096688C2778715236 @default.
• W97096688 hasConceptScore W97096688C2779130552 @default.
• W97096688 hasConceptScore W97096688C2779298103 @default.
• W97096688 hasConceptScore W97096688C2779465607 @default.
• W97096688 hasConceptScore W97096688C2781143361 @default.
• W97096688 hasConceptScore W97096688C2781413609 @default.
• W97096688 hasConceptScore W97096688C2781432083 @default.
• W97096688 hasConceptScore W97096688C29730261 @default.
• W97096688 hasConceptScore W97096688C2993143319 @default.

• next