Matches in SemOpenAlex for { <https://semopenalex.org/work/W97101587> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W97101587 endingPage "86" @default.
- W97101587 startingPage "677" @default.
- W97101587 abstract "Refractory or recurring leg ulcers typically signify the presence of impaired venous or arterial microcirculation (or both). A current hypothesis suggests that local oxygen and nutrient deficits occur because capillary lumens narrow and become permeable to fibrinogen and proteins by activated white blood cells and inadequate fibrinolysis. As a result, the deposition of a relatively impermeable perivascular fibrin sheath occurs, preventing adequate delivery of oxygen and nutrients. Therapy should therefore aim at reversing these deficits and improving wound healing. Pentoxifylline (Trental), used in combination with local wound care and appropriate antibiotic therapy, has been successful in significantly improving the healing of refractory leg ulcers. Pentoxifylline can reverse the abnormal function of white and red blood cells and platelets, as well as reduce blood viscosity and vascular permeability. The mechanisms of action of pentoxifylline are described in light of current hypotheses pertaining to leg ulcer development. Also discussed are nine cases in which pentoxifylline, when added to previously unsuccessful local wound care, either improved or healed the refractory ulcers." @default.
- W97101587 created "2016-06-24" @default.
- W97101587 creator A5002185085 @default.
- W97101587 date "1991-07-01" @default.
- W97101587 modified "2023-09-23" @default.
- W97101587 title "Pentoxifylline as adjunctive therapy in leg ulcer management." @default.
- W97101587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1938504" @default.
- W97101587 hasPublicationYear "1991" @default.
- W97101587 type Work @default.
- W97101587 sameAs 97101587 @default.
- W97101587 citedByCount "1" @default.
- W97101587 crossrefType "journal-article" @default.
- W97101587 hasAuthorship W97101587A5002185085 @default.
- W97101587 hasConcept C126322002 @default.
- W97101587 hasConcept C12722491 @default.
- W97101587 hasConcept C141071460 @default.
- W97101587 hasConcept C203014093 @default.
- W97101587 hasConcept C2779036427 @default.
- W97101587 hasConcept C2780269544 @default.
- W97101587 hasConcept C2780404050 @default.
- W97101587 hasConcept C54173615 @default.
- W97101587 hasConcept C71924100 @default.
- W97101587 hasConceptScore W97101587C126322002 @default.
- W97101587 hasConceptScore W97101587C12722491 @default.
- W97101587 hasConceptScore W97101587C141071460 @default.
- W97101587 hasConceptScore W97101587C203014093 @default.
- W97101587 hasConceptScore W97101587C2779036427 @default.
- W97101587 hasConceptScore W97101587C2780269544 @default.
- W97101587 hasConceptScore W97101587C2780404050 @default.
- W97101587 hasConceptScore W97101587C54173615 @default.
- W97101587 hasConceptScore W97101587C71924100 @default.
- W97101587 hasIssue "7" @default.
- W97101587 hasLocation W971015871 @default.
- W97101587 hasOpenAccess W97101587 @default.
- W97101587 hasPrimaryLocation W971015871 @default.
- W97101587 hasRelatedWork W1838368612 @default.
- W97101587 hasRelatedWork W201370233 @default.
- W97101587 hasRelatedWork W2167541347 @default.
- W97101587 hasRelatedWork W2312560553 @default.
- W97101587 hasRelatedWork W2417681107 @default.
- W97101587 hasRelatedWork W2786442507 @default.
- W97101587 hasRelatedWork W3025095098 @default.
- W97101587 hasRelatedWork W3195831281 @default.
- W97101587 hasRelatedWork W62844564 @default.
- W97101587 hasRelatedWork W97101587 @default.
- W97101587 hasVolume "91" @default.
- W97101587 isParatext "false" @default.
- W97101587 isRetracted "false" @default.
- W97101587 magId "97101587" @default.
- W97101587 workType "article" @default.