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- W97110117 abstract "Abnormalities at chromosome 11q23 can be found in many different kinds of leukemia. At the molecular level, a gene named MLL is involved in all these translocations. The 5′-region of this gene is fused to the 3′-part of different translocation partner genes resulting in transcription of a hybrid mRNA [1]. Most 11q23 abnormalities are clinically relevant. Patients bearing a translocation t(4;11), for example, have a very poor prognosis [2]. For this reason, routine diagnositic techniques are required. Conventional karyotyping, however, is rather time consuming and does only provide sufficient results in about 60% of the bone marrow specimens examined. Based on the PCR, much more sensitive assays became available during the last years. Usually, these techniques enable a sufficient analysis in more than 90% of the samples. However, an increasing number of detectable chromosomal translocations and a limited amount of patient’s material require a restriction of the number of PCR-assays to be performed from each sample. Multiplex-PCR using several primers in a single PCR-reaction tube may overcome some of these problems and enable the detection of different chromosomal translocations by a single PCR-reaction. Translocations involving the q23 region of chromosome 11 seem to be an ideal target for this procedure, because acute leukemias of different lineages have similar MLL gene fusion sites at 11q23. For this reason, a combination an MLL specific primer with 3 other primers, each specific for a possible translocation partner gene, may enable the detection of 3 different 11q23 abnormalities by a single assay." @default.
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- W97110117 date "1996-01-01" @default.
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- W97110117 title "Detection of Different 11q23 Chromosomal Abnormalities by Multiplex-PCR Using Automatic Fluorescence-Based DNA-Fragment Analysis" @default.
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- W97110117 doi "https://doi.org/10.1007/978-3-642-78907-6_84" @default.
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