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- W97151207 abstract "A newly-developed technique for determination of the ATP content of individual red cells to the densest, and hence presumably the oldest, cells from normal human blood was applied. It was found that these cells contain normal concentrations of ATP, although the net content of ATP is decreased. The essence of the technique is suspension of red cells in autologous plasma containing luciferin and luciferase, lysis of the cells with a pulse from a laser, and counting of the photoemissions resulting from reaction of the released ATP with the luciferase. These data appear to disprove the otherwise plausible hypothesis of Lichtman that red cells decline exponentially in ATP content as they age, by one of the suggested tests of this hypothesis. The data suggest an alternative hypothesis: red cells maintain an approximately constant concentration of ATP as they age, and red cell destruction is caused by factors other than cellular ATP." @default.
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- W97151207 date "1978-01-01" @default.
- W97151207 modified "2023-09-26" @default.
- W97151207 title "''Aged'' (dense) circulating red cells contain normal concentrations of ATP" @default.
- W97151207 doi "https://doi.org/10.2172/6230591" @default.
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