Matches in SemOpenAlex for { <https://semopenalex.org/work/W97161878> ?p ?o ?g. }
- W97161878 endingPage "8" @default.
- W97161878 startingPage "1750" @default.
- W97161878 abstract "A novel monoclonal antibody (mAB) TIA-1, which recognizes a 15-kd granule-associated protein of cytotoxic T lymphocytes and natural killer cells, has been applied to sections of lymph nodes with human immunodeficiency virus (HIV)-induced lymphadenopathy (follicular hyperplasia and lymphocyte depletion). The protein recognized by this mAB induces apoptosis in permeabilized lymphocytes in vitro. While this mAB reacted with approximately 46% of paracortical CD8+ cells in control nodes, it reacted with 75% of such cells in HIV-induced follicular hyperplasia. Germinal centers of the control nodes contained few TIA-1 + cells; in follicular hyperplasia caused by HIV-1, almost all germinal center CD8+ cells were TIA-1 +. Both in the control nodes and in HIV-induced follicular hyperplasia the majority of TIA-1 + cells coexpressed CD45R0. A marked loss of CD8+TIA-1+ cells was seen in lymphocyte-depleted nodes of patients with AIDS. The loss of these cytotoxic T lymphocytes may have a significant impact on the progression of the disease." @default.
- W97161878 created "2016-06-24" @default.
- W97161878 creator A5005155284 @default.
- W97161878 creator A5023840219 @default.
- W97161878 creator A5044431105 @default.
- W97161878 creator A5047594340 @default.
- W97161878 creator A5062495915 @default.
- W97161878 creator A5081429602 @default.
- W97161878 creator A5084966857 @default.
- W97161878 date "1993-06-01" @default.
- W97161878 modified "2023-09-23" @default.
- W97161878 title "Cytotoxic effector cell granules recognized by the monoclonal antibody TIA-1 are present in CD8+ lymphocytes in lymph nodes of human immunodeficiency virus-1-infected patients." @default.
- W97161878 cites W1523058583 @default.
- W97161878 cites W1525840776 @default.
- W97161878 cites W1574647877 @default.
- W97161878 cites W1599540448 @default.
- W97161878 cites W1601351723 @default.
- W97161878 cites W1877478601 @default.
- W97161878 cites W1964072966 @default.
- W97161878 cites W1968773871 @default.
- W97161878 cites W1972462680 @default.
- W97161878 cites W1976340479 @default.
- W97161878 cites W2003227439 @default.
- W97161878 cites W2019790475 @default.
- W97161878 cites W2029118025 @default.
- W97161878 cites W204100860 @default.
- W97161878 cites W2047750276 @default.
- W97161878 cites W205401375 @default.
- W97161878 cites W2067244066 @default.
- W97161878 cites W2088308807 @default.
- W97161878 cites W2088319043 @default.
- W97161878 cites W2116774061 @default.
- W97161878 cites W2124314287 @default.
- W97161878 cites W2134284956 @default.
- W97161878 cites W2136045513 @default.
- W97161878 cites W2163715113 @default.
- W97161878 cites W2209844256 @default.
- W97161878 cites W2304190202 @default.
- W97161878 cites W2312372446 @default.
- W97161878 cites W2397559663 @default.
- W97161878 cites W2413476350 @default.
- W97161878 cites W2423371852 @default.
- W97161878 cites W275674812 @default.
- W97161878 cites W333356916 @default.
- W97161878 cites W66811952 @default.
- W97161878 cites W70341877 @default.
- W97161878 cites W74632471 @default.
- W97161878 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1886982" @default.
- W97161878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8506945" @default.
- W97161878 hasPublicationYear "1993" @default.
- W97161878 type Work @default.
- W97161878 sameAs 97161878 @default.
- W97161878 citedByCount "30" @default.
- W97161878 countsByYear W971618782015 @default.
- W97161878 countsByYear W971618782017 @default.
- W97161878 countsByYear W971618782018 @default.
- W97161878 countsByYear W971618782022 @default.
- W97161878 countsByYear W971618782023 @default.
- W97161878 crossrefType "journal-article" @default.
- W97161878 hasAuthorship W97161878A5005155284 @default.
- W97161878 hasAuthorship W97161878A5023840219 @default.
- W97161878 hasAuthorship W97161878A5044431105 @default.
- W97161878 hasAuthorship W97161878A5047594340 @default.
- W97161878 hasAuthorship W97161878A5062495915 @default.
- W97161878 hasAuthorship W97161878A5081429602 @default.
- W97161878 hasAuthorship W97161878A5084966857 @default.
- W97161878 hasConcept C134018914 @default.
- W97161878 hasConcept C142724271 @default.
- W97161878 hasConcept C147483822 @default.
- W97161878 hasConcept C154317977 @default.
- W97161878 hasConcept C159047783 @default.
- W97161878 hasConcept C159654299 @default.
- W97161878 hasConcept C167672396 @default.
- W97161878 hasConcept C202751555 @default.
- W97161878 hasConcept C203014093 @default.
- W97161878 hasConcept C2777562237 @default.
- W97161878 hasConcept C2777761686 @default.
- W97161878 hasConcept C2778453870 @default.
- W97161878 hasConcept C2779720271 @default.
- W97161878 hasConcept C2780849966 @default.
- W97161878 hasConcept C2908591792 @default.
- W97161878 hasConcept C542903549 @default.
- W97161878 hasConcept C55493867 @default.
- W97161878 hasConcept C71924100 @default.
- W97161878 hasConcept C86803240 @default.
- W97161878 hasConcept C96926380 @default.
- W97161878 hasConceptScore W97161878C134018914 @default.
- W97161878 hasConceptScore W97161878C142724271 @default.
- W97161878 hasConceptScore W97161878C147483822 @default.
- W97161878 hasConceptScore W97161878C154317977 @default.
- W97161878 hasConceptScore W97161878C159047783 @default.
- W97161878 hasConceptScore W97161878C159654299 @default.
- W97161878 hasConceptScore W97161878C167672396 @default.
- W97161878 hasConceptScore W97161878C202751555 @default.
- W97161878 hasConceptScore W97161878C203014093 @default.
- W97161878 hasConceptScore W97161878C2777562237 @default.
- W97161878 hasConceptScore W97161878C2777761686 @default.
- W97161878 hasConceptScore W97161878C2778453870 @default.