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- W971654547 abstract "This chapter reviews classical techniques and describes recent methods to study ion channels on single myelinated fibers. A single myelinated fiber is composed of a single axon wrapped by the myelin sheath of Schwann cells. The axon is about 10–15 μm in diameter, and each Schwann cell and its associated myelin span about 1000–2000 μm along the axon. The axon covered by the myelin sheath is termed the “internodal axon.” Both axons and Schwann cells express voltage-gated ion channels. There are multiple types of channels. Schwann cells can be obtained in culture, in which sciatic nerves from newborn rats are minced, dissociated into single cells, and placed onto tissue wells. These single cells can then be subjected to standard whole-cell patch clamping. Because Schwann cells undergo dedifferentiation once they are separated from axons, the channel properties of cultured Schwann cells need not represent those found in vivo. Schwann cells retaining a myelin sheath and association with axons can be acutely isolated from newborn and adult rats for patch-clamp analysis. Gigaseals can be formed on the internodal surface between the cell body and the paranode. This membrane represents the outermost membrane of the Schwann cell before the spiraling of the membrane toward the internodal axon begins." @default.
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- W971654547 date "1994-01-01" @default.
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- W971654547 title "Biophysical Studies of Ion Channels in Glial Cells and Axons of Myelinated Nerves" @default.
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- W971654547 doi "https://doi.org/10.1016/b978-0-12-185287-0.50012-0" @default.
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