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- W97192862 abstract "AIM: To sumarize the clinical features of patients with SARS in early stage. METHODS: The clinical data of patients with SARS who were admitted to hospitals in the periods of 1 to 7 days after onset of illness. The early stage of SARS was identified by the syndromes and signs of lungs, oxygenation index and the examination of imaging. RESULTS: The positive rates of the reference parameters were similar in the 1st day and 2nd to 3rd day, but changed obviously in the later days. The period of 1 to 3 days was therefore considered as the early stage of SARS. The study showed that 88.7 percent of patients got fever, 98.8 percent of patients had reported fever and 16.3 % patients with chilly, 4.3 percent of patients even shiver. 20 percent of patients had the unspecific syndrome, such as fatigue, headache, myalgia, and arthralgia. 16.1% patients had congestion in throat and 8.4% patients with pharyngalgia. Rhinorrhea, sneezing, skin rash and tumefaction of tonsil or lymph nodes were rare (the rates were 3.4%, 2.5%, 0.9% and 0.3% respectively). 4.3 percent of patients occurred dianrrhea, but no hematenesis and hematochezia. Nausea, vomiting and other positive signs of abdumen were not common. About one third patients presented cough, 14.6% expectoration, 7% chest distress and suffocated. The sign of lung was usually lacked, and the rate of moist rales were only 4.9%. 71.4% patients‘ artery pressure of oxygen decreased, 20.9% and 27. 8% patients oxygenation index and oxygen satureation also went down slightly. The reducing rate of WBC, lymphocyte and PLT were 22.5%, 36.4% and 13.4% respectively, but there were 6.4% patients with high WBC count. The mean counts of CD3, CD4, and CD8 cells decreased obviously and their positive rates were more than 90%. Most patients of SARS (about 80% to 90%) had inflammatory shadow in chest films, majority had one lungfield shadow and minority with multi-lungfields, but some patients had normal films of chest X-ray (19.9%) and CT (9.1%). 10-15% patients‘ liver and renal functions were abnormal. 13-16% patients with high values of creatinine kinase, but that of CK-MB was only 5.9%. CONCLUSION: In early stage of SARS (1 to 3 days), almost all the patients get fever, some have the unspecific symptom, but the sign of catarrh and tumefaction of lymph nodes are rare. About one third patients have cough and 14.6% expectoration, and present mild hypoxemia, but usually lack the sign of lung. In 22.5% and 36.4% patients WBC and lymphocyte reduce, and also the mean counts of CD3, CD4 and CD8 cells reduce significantly, the positive rates are more than 90%. About 80% (X-ray) to 90% (CT) patients show abnormal chest films in radiologic examination, but someones have the normal results of chest X-ray (19.9%) and CT (9.1%). About 10-16% patients suffer the damage of the liver, kidney and heart." @default.
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- W97192862 date "2004-01-01" @default.
- W97192862 modified "2023-09-23" @default.
- W97192862 title "Characteristics of 1 062 patients with SARS in early stage in Beijing" @default.
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- W97192862 doi "https://doi.org/10.11569/wcjd.v12.i5.1149" @default.
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