Matches in SemOpenAlex for { <https://semopenalex.org/work/W97193217> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W97193217 endingPage "6153" @default.
- W97193217 startingPage "6150" @default.
- W97193217 abstract "N-Chloro-D-leucine is an irreversible inhibitor or D-amino acid oxidase on a time scale of seconds. Studies with N-[36C]chloro-D-leucine, N-chloro-D-[1-14C]leucine and N-chloro-D-[4,5-3H]leucine show that the modified enzyme has been chlorinated at a site, or sites, on the apoenzyme. The 36Cl measurements agree with titrations of catalytic activity in showing that two chlorine equivalents are incorporated per active site flavin. Kinetically, the interaction with N-chloro-D-leucine behaves in a manner which is consistent with consecutive chlorinations of an amino acid residue, or residues, in the active site region by the first 2 molecules of N-chloro-D-leucine to be processed by the enzyme. The effect of chlorination of the enzyme on the steady state parameters for oxidation of D-alanine is entirely explained by a single perturbation, namely, a 1000-fold reduction in the specific rate of flavin reduction as measured directly by rapid reaction techniques." @default.
- W97193217 created "2016-06-24" @default.
- W97193217 creator A5018929315 @default.
- W97193217 creator A5027378652 @default.
- W97193217 date "1976-10-01" @default.
- W97193217 modified "2023-09-30" @default.
- W97193217 title "Active site chlorination of D-amino acid oxidase by N-chloro-D-leucine." @default.
- W97193217 cites W1537541495 @default.
- W97193217 cites W1570548591 @default.
- W97193217 cites W1598071110 @default.
- W97193217 cites W1678484927 @default.
- W97193217 cites W2040662170 @default.
- W97193217 cites W2333938516 @default.
- W97193217 cites W2403803025 @default.
- W97193217 doi "https://doi.org/10.1016/s0021-9258(17)33072-7" @default.
- W97193217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9413" @default.
- W97193217 hasPublicationYear "1976" @default.
- W97193217 type Work @default.
- W97193217 sameAs 97193217 @default.
- W97193217 citedByCount "12" @default.
- W97193217 crossrefType "journal-article" @default.
- W97193217 hasAuthorship W97193217A5018929315 @default.
- W97193217 hasAuthorship W97193217A5027378652 @default.
- W97193217 hasBestOaLocation W971932171 @default.
- W97193217 hasConcept C181199279 @default.
- W97193217 hasConcept C185592680 @default.
- W97193217 hasConcept C2776580952 @default.
- W97193217 hasConcept C2778239910 @default.
- W97193217 hasConcept C38485361 @default.
- W97193217 hasConcept C515207424 @default.
- W97193217 hasConcept C55493867 @default.
- W97193217 hasConceptScore W97193217C181199279 @default.
- W97193217 hasConceptScore W97193217C185592680 @default.
- W97193217 hasConceptScore W97193217C2776580952 @default.
- W97193217 hasConceptScore W97193217C2778239910 @default.
- W97193217 hasConceptScore W97193217C38485361 @default.
- W97193217 hasConceptScore W97193217C515207424 @default.
- W97193217 hasConceptScore W97193217C55493867 @default.
- W97193217 hasIssue "19" @default.
- W97193217 hasLocation W971932171 @default.
- W97193217 hasOpenAccess W97193217 @default.
- W97193217 hasPrimaryLocation W971932171 @default.
- W97193217 hasRelatedWork W1983192825 @default.
- W97193217 hasRelatedWork W2017894961 @default.
- W97193217 hasRelatedWork W2024862657 @default.
- W97193217 hasRelatedWork W2031158222 @default.
- W97193217 hasRelatedWork W2046498090 @default.
- W97193217 hasRelatedWork W2051826279 @default.
- W97193217 hasRelatedWork W2061897484 @default.
- W97193217 hasRelatedWork W2111408571 @default.
- W97193217 hasRelatedWork W2126863462 @default.
- W97193217 hasRelatedWork W2135997515 @default.
- W97193217 hasVolume "251" @default.
- W97193217 isParatext "false" @default.
- W97193217 isRetracted "false" @default.
- W97193217 magId "97193217" @default.
- W97193217 workType "article" @default.