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- W97198179 abstract "Heat Shock Proteins (HSP) are a diverse group of proteins that as molecular chaperons bind to a variety of cell proteins in all cells. HSP also play a significant role in helping the immune system recognize diseased cells. During the past three decades, HSP are found to be a potent agent for tumor immunotherapy and studies towards anti-tumor vaccine development still continue today. HSP-based immunotherapies, which could augment antigen-specific immune responses, are the promising approaches for effective treatment and enduring cure. However, more studies on the role of HSP to induce innate and adaptive immune responses have resulted in new understanding of HSP in immunotherapy. Certain HSP are over expressed in tumor cells and aid tumor cells metastasis. Under this circumstance, HSP were chosen as targets for cancer treatments. Recent evidence further demonstrated that HSP possess immunoregulatory attributes. The high evolutionary conservancy of HSP and their overexpression during inflammation make them as important pathogen-related antigens as well as self antigens. Certain HSP (specifically Hsp60, Hsp65, Hsp70 and Hsp10) have been identified to be involved in the regulation of some autoimmune diseases. Now HSP becomes a double-sided sword. Therefore, HSP are also a tool for manipulating autoimmune inflammation and HSP for immunotherapy of autoimmune diseases are under discovery" @default.
- W97198179 created "2016-06-24" @default.
- W97198179 creator A5053078476 @default.
- W97198179 creator A5070711590 @default.
- W97198179 date "2009-11-25" @default.
- W97198179 modified "2023-09-26" @default.
- W97198179 title "Heat Shock Protein (HSP)-Based Immunotherapies" @default.
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- W97198179 doi "https://doi.org/10.1007/978-90-481-3381-9_8" @default.
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