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- W972084767 abstract "目的探讨功能性便秘（functional constipation．FC）儿童肠道微生态菌落的构成及其在便秘发生过程中的作用。方法研究对象分为便秘组和对照组．便秘组15例，平均年龄6．5岁．对照组35例，平均年龄6岁。取所有儿童粪便提取细菌基因组DNA，应用基于细菌16SrDNA的PCR—SK2P技术和基于细菌基因组的BOX—PCR技术对肠道菌落的DNA指纹图谱分析，结合克隆测序和生物信息学技术对FC儿童的肠道菌落进行初步鉴定，并对其组成结构进行分析。结果对照组和便秘组的所有样品分别进行3次以上的PCR—SSCP和BOX—PCR指纹图谱分析，得到了稳定可重复的罔谱。便秘组菌种的种类较对照组明显增多．差异有统计学意义；对照组优势菌主要为拟杆菌属、埃希氏菌属、双歧杆菌属、乳杆菌属；便秘组的优势菌主要为脆弱拟杆菌属、埃希氏菌属、真杆菌属和梭菌属。结论功能性便秘儿童肠道菌群的菌属多样性增加．各肠道菌属间存在比例失调．肠道微生态失调可能参与了便秘的产生或加重过程。" @default.
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- W972084767 date "2009-01-01" @default.
- W972084767 modified "2023-09-24" @default.
- W972084767 title "功能性便秘儿童肠道菌群DNA的PCR—SSCP和BOX—PCR指纹图谱分析及临床意义" @default.
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