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- W972470331 abstract "Stylopeptide 1 synthesized and isolated from different sources exhibits a large activity difference in inhi- bitory effect on the growth of a cancer cell. Based on the different amounts of methanol and water during synthesis, isolation and purification of the cyclic peptides, molecular dynamics(MD) was employed to simulate the conforma- tion of stylopeptide 1 in methanol and aqueous environments. The comparative results show that the backbone ring was more rigid in methanol than in water. In methanol, two β-turns and three hydrogen bonds were well conserved throughout the simulation, whereas no hydrogen bonds or turns were preserved in water. The activity difference of stylopeptide 1 seemed to be attributed to the solvent effect on its conformation." @default.
- W972470331 created "2016-06-24" @default.
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- W972470331 date "2009-10-16" @default.
- W972470331 modified "2023-09-28" @default.
- W972470331 title "Solvent Effect on Conformation of a Cycloheptapeptide, Stylopeptide 1, Evaluated by Molecular Dynamics in Methonal and Aqueous Environments" @default.
- W972470331 hasPublicationYear "2009" @default.
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