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- W972512851 abstract "Publisher Summary This chapter discusses the glycosyltransferases that carry out the elongation of complex N-glycosyl oligosaccharides. Glycoproteins contain high-mannose oligosaccharides, complex oligosaccharides, or both. The (Man) 5 (GlcNAc) 2 -Asn intermediate is the starting point for all complex N -glycosyl oligosaccharides. A series of Golgi apparatus-localized glycosyltransferases and α-mannosidases act on this compound to produce several classes of complex structures. The key enzyme in the initiation of complex oligosaccharide synthesis is called UDP-GlcNAc: α-D-mannoside βl-2-N-acetylglucosaminyltransferase I (GlcNAc-transferase I). GlcNAc-transferase I adds a GlcNAc in βl-2 linkage to the Man-αl-3 arm of the 5-Man intermediate. This enzyme must act before the last two Man residues are removed by highly specific α-mannosidases to yield the (Man) 3 (GlcNAc) 2 -Asn core present in all complex oligosaccharides. The Golgi apparatus is the cellular site where not only N -glycosyl oligosaccharides receive their more terminal sugars, but also Ser(Thr)-GalNAc oligosaccharides, xylosyl-serine oligosaccharides, and hydroxylysine-galactose oligosaccharides." @default.
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- W972512851 date "1983-01-01" @default.
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- W972512851 title "[10] Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type" @default.
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- W972512851 doi "https://doi.org/10.1016/0076-6879(83)98143-0" @default.
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