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- W972593463 endingPage "77" @default.
- W972593463 startingPage "67" @default.
- W972593463 abstract "Ischemic stroke is a major cause of death and long-term disability worldwide. Thrombolysis with recombinant tissue plasminogen activator is the only proven and effective treatment for acute ischemic stroke; however, therapeutic hypothermia is increasingly recognized as having a tissue-protective function and positively influencing neurological outcome, especially in cases of ischemia caused by cardiac arrest or hypoxic–ischemic encephalopathy in newborns. Yet, many aspects of hypothermia as a treatment for ischemic stroke remain unknown. Large-scale studies examining the effects of hypothermia on stroke are currently underway. This review discusses the mechanisms underlying the effect of hypothermia, as well as trends in hypothermia induction methods, methods for achieving optimal protection, side effects, and therapeutic strategies combining hypothermia with other neuroprotective treatments. Finally, outstanding issues that must be addressed before hypothermia treatment is implemented at a clinical level are also presented." @default.
- W972593463 created "2016-06-24" @default.
- W972593463 creator A5026771763 @default.
- W972593463 creator A5078037174 @default.
- W972593463 creator A5080693274 @default.
- W972593463 creator A5082664929 @default.
- W972593463 date "2015-10-01" @default.
- W972593463 modified "2023-10-17" @default.
- W972593463 title "Therapeutic hypothermia for stroke: Where to go?" @default.
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