FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W972617295> ?p ?o ?g. }

• W972617295 endingPage "90" @default.
• W972617295 startingPage "5282" @default.
• W972617295 abstract "To analyze the causative mechanisms in refractory leukemia cells.Vascular endothelial growth factor (VEGF) blood plasma concentrations in 35 de novo, 6 relapse, 20 remission leukemia patients and 10 healthy kids were determined via ELISA analyses. Transcription levels of the VEGF receptors (VEGFR) Fms-like tyrosine kinase-1 (Flt-1) and kinase-domain insert containing receptor (KDR) were determined in participants' leucocytes with RT-PCR. Apoptosis rates as well as Cyt-C and Caspase-3 expression was determined in Jurkat, Jurkat(Bcl-2), healthy and recurrent leukemia leukocytes with and without VP-16 applications via flow cytometry. Total Akt (t-Akt) expression and its phosphorylation (p-AKT) status in leukocytes of the participants were analyzed with western blots.Healthy children and the remission group had the lowest blood plasma VEGF concentrations (91.16±41.34 vs. 135.80±111.28 pg/ml), followed by de novo leukemia patients (362.49±195.68 pg/ml-494.19±186.23 pg/ml) and relapse patients (574.37±278.45 pg/ml) (P<0.01). The same trend was statistically significant visible for Flt-1 and KDR expressions in leukocytes of the participants. Stable Bcl-2 overexpression led to reduced apoptosis rates as well as Cyt-C and Caspase-3 expressions in Jurkat cells after VP-16 application, which was similar in leucocytes of remission patients. In contrast to no phosphorylation in healthy children, Akt was phosphorylated in 10% remission samples, 30% de novo leukemia samples and in 67% of recurrent leukemia leucocytes.High VEGF plus VEGFR expression and AKT phosphorylation are highest in leukocytes of remission patients, suggesting VEGF signaling as a cause of reduced apoptosis susceptibility upon treatments." @default.
• W972617295 created "2016-06-24" @default.
• W972617295 creator A5002446630 @default.
• W972617295 creator A5008408386 @default.
• W972617295 creator A5019873683 @default.
• W972617295 creator A5037838431 @default.
• W972617295 creator A5049443510 @default.
• W972617295 creator A5073070877 @default.
• W972617295 creator A5073216396 @default.
• W972617295 creator A5081117163 @default.
• W972617295 date "2015-01-01" @default.
• W972617295 modified "2023-09-25" @default.
• W972617295 title "Up-regulation of VEGF and its receptor in refractory leukemia cells." @default.
• W972617295 cites W176326824 @default.
• W972617295 cites W1831026143 @default.
• W972617295 cites W1961810271 @default.
• W972617295 cites W1966215973 @default.
• W972617295 cites W1971436806 @default.
• W972617295 cites W1980969801 @default.
• W972617295 cites W1982421412 @default.
• W972617295 cites W1987080481 @default.
• W972617295 cites W2008492649 @default.
• W972617295 cites W2016939810 @default.
• W972617295 cites W2023915011 @default.
• W972617295 cites W2035673396 @default.
• W972617295 cites W2057258396 @default.
• W972617295 cites W2065919583 @default.
• W972617295 cites W2071497118 @default.
• W972617295 cites W2076426515 @default.
• W972617295 cites W2098615971 @default.
• W972617295 cites W2104768905 @default.
• W972617295 cites W2110630778 @default.
• W972617295 cites W2117834514 @default.
• W972617295 cites W2130594577 @default.
• W972617295 cites W2145260509 @default.
• W972617295 cites W2151101199 @default.
• W972617295 cites W2156792347 @default.
• W972617295 cites W2409559805 @default.
• W972617295 cites W2416025936 @default.
• W972617295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4503100" @default.
• W972617295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26191229" @default.
• W972617295 hasPublicationYear "2015" @default.
• W972617295 type Work @default.
• W972617295 sameAs 972617295 @default.
• W972617295 citedByCount "9" @default.
• W972617295 countsByYear W9726172952016 @default.
• W972617295 countsByYear W9726172952017 @default.
• W972617295 countsByYear W9726172952019 @default.
• W972617295 countsByYear W9726172952020 @default.
• W972617295 countsByYear W9726172952022 @default.
• W972617295 countsByYear W9726172952023 @default.
• W972617295 crossrefType "journal-article" @default.
• W972617295 hasAuthorship W972617295A5002446630 @default.
• W972617295 hasAuthorship W972617295A5008408386 @default.
• W972617295 hasAuthorship W972617295A5019873683 @default.
• W972617295 hasAuthorship W972617295A5037838431 @default.
• W972617295 hasAuthorship W972617295A5049443510 @default.
• W972617295 hasAuthorship W972617295A5073070877 @default.
• W972617295 hasAuthorship W972617295A5073216396 @default.
• W972617295 hasAuthorship W972617295A5081117163 @default.
• W972617295 hasConcept C11960822 @default.
• W972617295 hasConcept C126322002 @default.
• W972617295 hasConcept C153911025 @default.
• W972617295 hasConcept C167734588 @default.
• W972617295 hasConcept C170493617 @default.
• W972617295 hasConcept C179464577 @default.
• W972617295 hasConcept C190283241 @default.
• W972617295 hasConcept C203014093 @default.
• W972617295 hasConcept C2776090121 @default.
• W972617295 hasConcept C2777025900 @default.
• W972617295 hasConcept C2778461978 @default.
• W972617295 hasConcept C502942594 @default.
• W972617295 hasConcept C553184892 @default.
• W972617295 hasConcept C55493867 @default.
• W972617295 hasConcept C71924100 @default.
• W972617295 hasConcept C75217442 @default.
• W972617295 hasConcept C86803240 @default.
• W972617295 hasConcept C8891405 @default.
• W972617295 hasConcept C95444343 @default.
• W972617295 hasConceptScore W972617295C11960822 @default.
• W972617295 hasConceptScore W972617295C126322002 @default.
• W972617295 hasConceptScore W972617295C153911025 @default.
• W972617295 hasConceptScore W972617295C167734588 @default.
• W972617295 hasConceptScore W972617295C170493617 @default.
• W972617295 hasConceptScore W972617295C179464577 @default.
• W972617295 hasConceptScore W972617295C190283241 @default.
• W972617295 hasConceptScore W972617295C203014093 @default.
• W972617295 hasConceptScore W972617295C2776090121 @default.
• W972617295 hasConceptScore W972617295C2777025900 @default.
• W972617295 hasConceptScore W972617295C2778461978 @default.
• W972617295 hasConceptScore W972617295C502942594 @default.
• W972617295 hasConceptScore W972617295C553184892 @default.
• W972617295 hasConceptScore W972617295C55493867 @default.
• W972617295 hasConceptScore W972617295C71924100 @default.
• W972617295 hasConceptScore W972617295C75217442 @default.
• W972617295 hasConceptScore W972617295C86803240 @default.
• W972617295 hasConceptScore W972617295C8891405 @default.
• W972617295 hasConceptScore W972617295C95444343 @default.

• next