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• W97263494 abstract "We develop a three-level multiscale approach of the red blood cell (RBC) membrane and couple this approach with a boundary element method (BEM) for the surrounding Stokes flow to simulate the mechanical behavior of a RBC under various in vitro and in vivo conditions. Our multiscale approach of this membrane includes three models: in the whole cell level (Level III), a finite element method (FEM) is employed to model the lipid bilayer and the cytoskeleton as two distinct layers of shells with sliding -only interaction. The mechanical properties of the cytoskeleton are obtained from a coarse-grained molecular dynamics model (Level II) of the junctional complex. The spectrin, a major protein of the cytoskeleton, is simulated using a molecular-based constitutive model (Level I), including its domain folding/unfolding reactions. A BEM of the surrounding Stokes flow is coupled with the FEM model of the membrane through a staggered coupling algorithm. Using this method, we first predict the resting shapes of healthy and diseased RBCs. Secondly, we simulate three quasi-static experiments of the micropipette aspiration, the optical tweezer stretching, and the flow channel stretching. Detailed distributions of the bilayer-skeleton interaction force that may cause their dissociation and lead to phenomena such as vesiculation are predicted. Specifically, our model predicts a correlation between the occurrence of spectrin unfolding and increase in the mechanical load upon individual bilayer-skeleton pinning points in micropipette aspirations. A simulation of the necking process after bilayer-skeleton dissociation is also conducted. Thirdly, we study RBC dynamics in capillary flow and find that the skeleton density is large near the vessel wall, and the maximum bilayer-skeleton interaction force occurs at the trailing edge. Finally, we investigate the tumbling, tank- treading, and swinging motions of RBCs in shear flow. The dependencies of tank-treading frequency on the blood plasma viscosity and the membrane viscosity we found match well with the existing experimental and computational data. The simulation results show that during tank- treading there is almost no protein density variation of the skeleton due to the significant bilayer-skeleton friction. The distributions of shear deformation, bilayer- skeleton interaction forces are also predicted" @default.
• W97263494 created "2016-06-24" @default.
• W97263494 creator A5049068199 @default.
• W97263494 date "2011-01-01" @default.
• W97263494 modified "2023-09-27" @default.
• W97263494 title "Multiscale modeling of a red blood cell and its fluid- structure interaction" @default.
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• W97263494 cites W157495653 @default.
• W97263494 cites W1579526370 @default.
• W97263494 cites W1589288858 @default.
• W97263494 cites W1965780695 @default.
• W97263494 cites W1966985709 @default.
• W97263494 cites W1970916957 @default.
• W97263494 cites W1972784616 @default.
• W97263494 cites W1974199845 @default.
• W97263494 cites W1975244345 @default.
• W97263494 cites W1979592575 @default.
• W97263494 cites W1981054060 @default.
• W97263494 cites W1981160000 @default.
• W97263494 cites W1982911417 @default.
• W97263494 cites W1984827286 @default.
• W97263494 cites W1986140188 @default.
• W97263494 cites W1987106223 @default.
• W97263494 cites W1992221541 @default.
• W97263494 cites W1995950736 @default.
• W97263494 cites W1996236460 @default.
• W97263494 cites W1997828975 @default.
• W97263494 cites W1998580861 @default.
• W97263494 cites W2001764594 @default.
• W97263494 cites W2002464985 @default.
• W97263494 cites W2004365967 @default.
• W97263494 cites W2004938088 @default.
• W97263494 cites W2006615345 @default.
• W97263494 cites W2007035075 @default.
• W97263494 cites W2007924064 @default.
• W97263494 cites W2011687418 @default.
• W97263494 cites W2013446167 @default.
• W97263494 cites W2014157230 @default.
• W97263494 cites W2020152035 @default.
• W97263494 cites W2024377496 @default.
• W97263494 cites W2027348461 @default.
• W97263494 cites W2029364173 @default.
• W97263494 cites W2039196738 @default.
• W97263494 cites W2039494409 @default.
• W97263494 cites W2041408928 @default.
• W97263494 cites W2043033882 @default.
• W97263494 cites W2043866570 @default.
• W97263494 cites W2044121023 @default.
• W97263494 cites W2047153979 @default.
• W97263494 cites W2053046999 @default.
• W97263494 cites W2053546982 @default.
• W97263494 cites W2058120585 @default.
• W97263494 cites W2058520035 @default.
• W97263494 cites W2058912578 @default.
• W97263494 cites W2059579573 @default.
• W97263494 cites W2059835019 @default.
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• W97263494 cites W2061822804 @default.
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• W97263494 cites W2079878358 @default.
• W97263494 cites W2087274883 @default.
• W97263494 cites W2090353374 @default.
• W97263494 cites W2090616879 @default.
• W97263494 cites W2093012008 @default.
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• W97263494 cites W2111646717 @default.
• W97263494 cites W2114120944 @default.
• W97263494 cites W2114952318 @default.
• W97263494 cites W2117243692 @default.
• W97263494 cites W2121882207 @default.
• W97263494 cites W2131895213 @default.
• W97263494 cites W2137278399 @default.
• W97263494 cites W2148984048 @default.
• W97263494 cites W2150538380 @default.
• W97263494 cites W2152731714 @default.
• W97263494 cites W2158168989 @default.
• W97263494 cites W2158200659 @default.
• W97263494 cites W2163420000 @default.
• W97263494 cites W2163664662 @default.
• W97263494 cites W2165382719 @default.
• W97263494 cites W2166645901 @default.
• W97263494 cites W2168077579 @default.
• W97263494 cites W2168795107 @default.
• W97263494 cites W2171314935 @default.
• W97263494 cites W2303640187 @default.
• W97263494 cites W2339045296 @default.
• W97263494 cites W2395917550 @default.
• W97263494 cites W3100559697 @default.
• W97263494 cites W378753200 @default.
• W97263494 cites W421315060 @default.
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• W97263494 hasPublicationYear "2011" @default.
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