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- W972676210 abstract "We aimed to develop an MRI based protocol to investigate anatomical differences in brainstem blood vessels between spontaneously hypertensive rats (SHR; n=4) and their normotensive progenitor strain Wistar Kyoto (WKY; n=4) rats. These were compared using high-resolution multislice, 2D time of flight (TOF) Magnetic Resonance Angiography using different gadolinium (Gd) based contrast agents (Gd-Albumin, Gadodiamide) to image cerebral blood vessels at 4.7T (TR/TE=18ms/4.3ms, matrix=512x320,nslices=80; nex=4, flip=35°, resolution=68x67x500μm3). Tissue perfusion was measured using dynamic contrast enhancement (TR/TE=12ms/2.8ms, matrix=256x128, nslices=1; nex=1, ΔT=1.5s, images=300, flip=15°, resolution=0.137x0.230x1mm3) or by determining changes in tissue transverse relaxation time pre- and post-contrast enhancement. Images were processed and 3D rendered using Osirix (Mac OS10.4 compatible version). We propose that our protocol will allow measurement and comparison of both blood vessel diameters and tissue perfusion in central cardioregulatory regions in the respective rat strains. Supported by NIH grants HL33610 and 76312." @default.
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- W972676210 date "2008-03-01" @default.
- W972676210 modified "2023-10-06" @default.
- W972676210 title "Developing an MRI based method for analyzing differences in blood vessel diameter and brain tissue perfusion in hypertension" @default.
- W972676210 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1210.21" @default.
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