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- W972693106 abstract "Schizophrenia is increasingly recognized as a neurodevelopmental disease with an additional degenerative component, comprising cognitive decline and loss of cortical gray matter. We hypothesized that a neuroprotective/neurotrophic add-on strategy, recombinant human erythropoietin (rhEPO) in addition to stable antipsychotic medication, may be able to improve cognitive function. Therefore, we designed a double-blind, placebo-controlled, randomized, multicenter, proof-of-principle study. Chronic schizophrenic men (N=39) with defined cognitive deficit, stable medication and disease state, were treated for 3 months with a weekly intravenous infusion of 40,000 IU rhEPO (N=20) or placebo (N=19) and neuropsychologically testet at 2 weeks, 4 weeks and 12 weeks of study participation. Both placebo and rhEPO patients improved in all evaluated categories. Patients receiving rhEPO showed a significant improvement over placebo patients in schizophrenia-related cognitive performance (RBANS subtests, Cognitive Sum Score). The fact that rhEPO is the first compound to exert a selective and lasting beneficial effect on cognition should encourage new treatment strategies for schizophrenia." @default.
- W972693106 created "2016-06-24" @default.
- W972693106 creator A5052088581 @default.
- W972693106 date "2022-02-17" @default.
- W972693106 modified "2023-09-30" @default.
- W972693106 title "Verbesserung kognitiver Leistungen bei chronischer Schizophrenie durch rekombinantes humanes Erythropoietin (rhEPO)" @default.
- W972693106 doi "https://doi.org/10.53846/goediss-268" @default.
- W972693106 hasPublicationYear "2022" @default.
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