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- W97284346 abstract "Kiserleteinkben azonositott agykergi idegsejtek szerepet vizsgaltuk a neuronhalozatban. Azt talaltuk, hogy a neurogliaform sejtek a nemcsak egymassal alakitanak ki elektromos szinapszisokat, ahogyan az a tobbi gatlo sejttipusnal megfigyelhető, hanem tobb GABAerg sejtpopulacioval is elektromos szinaptikus osszekottetest hoznak letre. Kimutattuk, hogy a neurogliaform sejtek egyetlen akcios potencialja elegendő az agykergi lassu GABAA valaszok kialakitasara, amelyek igen szokatlan tulajdonsagokkal rendelkeznek: rendkivul lassu kinetika, alacsony GABA koncentracio es a transzmitter diffuzioja a szinaptikus resen kivulre. Adaptaltuk az agyszeleteken vegzett szimultan tobbszoros patch clamp technikat emberi agykereg vizsgalatara. Bizonyitottuk, hogy az emberi agykeregben is műkodnek elektromos szinapszisok es hogy az emberi neurogliaform sejtek, a patkanyban leirtakhoz hasonloan lassu, GABAA es GABAB receptorokon at műkodő gatlast alakitanak ki. Elsőkent alkalmaztunk ugyanazon problema vizsgalatara nagyfelbontasu immuncitokemiai es elektrofiziologiai modszerekkel kombinalt ketfoton kepalkotast es eddig ismeretlen, terszelektiv eltavolito mechanizmust tartunk fel az idegsejteken beluli jeltovabbitasban kiemelt szerepet jatszo kalcium ionok terbeli eloszlasat meghatarozo folyamatokban. Kimutattuk, hogy a kandelaber sejtek, amelyeket a leghatekonyabb gatlo sejtnek hittek az agykeregben, a ma ismert leghatekonyabb serkentő sejtek lehetnek az ember es a patkany agykergeben egyarant. | We investigated the function of identified neurons in microcircuits of the cerebral cortex. We found that neurogliaform cells form homologous electrical synapses among themselves, similar to other types of cortical interneuron. However, neurogliaform cells also establish heterologous electrical synapses with different GABAergic cells. We also showed that neurogliaform cells are specialized to a unique form of GABAergic communication. A single action potential of a neurogliaform cells is sufficient to trigger the so-called slow GABAA responses in the cortex, which have unique synaptic properties: extremely slow kinetics, low GABA concentration and the diffusion of the transmitter outside the synaptic cleft. We have adapted the in vitro multiple patch clamp method to study samples taken from adult human cerebral cortex. We recorded the first synaptic interactions in the human cortex and showed that electrical synapses exist between human neurons. We also confirmed that human neurogliaform cells, similar to the rat, elicit slow, GABA and GABAB receptor mediated responses. We pioneered the combination of high resolution immunocytochemistry with two-photon imaging and revealed a novel, spatially selective extrusion mechanism in the regulation of intracellular calcium dynamics. We showed that chandelier cells, which were considered to be most powerful inhibitory neurons of the nervous system, can act as uniquely effective excitatory neurons in the human and rat cerebral cortex." @default.
- W97284346 created "2016-06-24" @default.
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- W97284346 date "2008-01-01" @default.
- W97284346 modified "2023-10-12" @default.
- W97284346 title "Neurogliaform sejtek funkcionális analízise az agykérgi információ-feldolgozásban = Functional analysis of neurogliaform cells in cortical information processing" @default.
- W97284346 hasPublicationYear "2008" @default.
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