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- W97319181 abstract "Recent advances in red blood cell metabolomics have paved the way for further improvements of storage solutions.In the present study, we exploited a validated high performance liquid chromatography-mass spectrometry analytical workflow to determine the effects of vitamin C and N-acetylcysteine supplementation (anti-oxidants) on the metabolome of erythrocytes stored in citrate-phosphate-dextrose saline-adenine-glucose-mannitol medium under blood bank conditions.We observed decreased energy metabolism fluxes (glycolysis and pentose phosphate pathway). A tentative explanation of this phenomenon could be related to the observed depression of the uptake of glucose, since glucose and ascorbate are known to compete for the same transporter. Anti-oxidant supplementation was effective in modulating the redox poise, through the promotion of glutathione homeostasis, which resulted in decreased haemolysis and less accumulation of malondialdehyde and oxidation by-products (including oxidized glutathione and prostaglandins).Anti-oxidants improved storage quality by coping with oxidative stress at the expense of glycolytic metabolism, although reservoirs of high energy phosphate compounds were preserved by reduced cyclic AMP-mediated release of ATP." @default.
- W97319181 created "2016-06-24" @default.
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- W97319181 date "2014-07-01" @default.
- W97319181 modified "2023-10-12" @default.
- W97319181 title "Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview." @default.
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- W97319181 doi "https://doi.org/10.2450/2014.0266-13" @default.
- W97319181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4111820" @default.
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