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- W973348549 abstract "This chapter discusses the modeling of mammalian P450s on basis of P450cam X-ray structure. The power of recombinant DNA technology and mutagenesis methods can be employed for structure–function studies. The primary focus of such studies is to understand the relationship between structure and substrate specificity within and between P450 families. More far-reaching goals include the design of specific P450 inhibitors important for therapeutic and agrochemical uses and the engineering of P450s designed to catalyze important stereospecific hydroxylation reactions. To provide a structural basis for these diverse goals, reference to a three-dimensional structure is essential. However, while there are a large and increasing number of primary sequences, there is only one X-ray structure available: that of the bacterial P450cam." @default.
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- W973348549 date "1991-01-01" @default.
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- W973348549 title "[2] Modeling of mammalian P450s on basis of P450cam x-ray structure" @default.
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- W973348549 doi "https://doi.org/10.1016/0076-6879(91)06073-c" @default.
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