Matches in SemOpenAlex for { <https://semopenalex.org/work/W97376612> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W97376612 endingPage "62" @default.
- W97376612 startingPage "157" @default.
- W97376612 abstract "Thrombokinetograms are graphic depictions of the optical changes occurring in plasma during the clotting process and provide information, not only on the time required for clotting to begin, but also on the way in which the clot forms. We studied thrombokinetic profiles in plasmas from normal dogs, and dogs with varying degrees of factor VIII deficiency. Clotting was induced through intrinsic, extrinsic and common coagulation pathways [activated partial thromboplastin time, prothrombin time and thrombin time, respectively]. The thrombokinetograms for the various clotting tests were qualitatively similar in normal canine plasmas. After activation of the clotting system there was a period in which no change in optical density occurred. This period was represented by the left base line and corresponded to the duration of the clotting time. When fibrin production commenced there was a rapid increase in the rate of optical density change (DeltaOD) to a maximum (V(max)DeltaOD) in time t(1). This was followed by a more gradual reduction in DeltaOD in time t(2). The activated partial thromboplastin time thrombokinetograms for von Willebrand's disease plasmas were characterized by a reduced V(max)DeltaOD and prolonged t(1). In severe hemophilic plasma [factor VIII coagulant (F VIII:C)<1% of normal] there was a very slow increase in DeltaOD following a prolonged left baseline. The V(max)DeltaOD, t(1) and t(2) could not be determined since a peak was not attained in one minute. The prothrombin and thrombin time thrombokinetograms for von Willebrand's disease plasmas were normal. The prothrombin time thrombokinetogram for hemophilic plasma had a 2X normal V(max)DeltaOD possibly related to the relatively high fibrinogen concentration of this plasma compared to the normal. Changes in thrombokinetogram profiles may be of value in studying mild to moderate clotting factor deficiencies particularly where the clotting times are not markedly prolonged." @default.
- W97376612 created "2016-06-24" @default.
- W97376612 creator A5019952675 @default.
- W97376612 date "1983-04-01" @default.
- W97376612 modified "2023-09-23" @default.
- W97376612 title "Thrombokinetic studies in normal and factor VIII-deficient canine plasmas." @default.
- W97376612 cites W135211587 @default.
- W97376612 cites W1842141317 @default.
- W97376612 cites W2035850311 @default.
- W97376612 cites W2064915305 @default.
- W97376612 cites W2322684140 @default.
- W97376612 cites W2328930329 @default.
- W97376612 cites W2418892018 @default.
- W97376612 cites W323262411 @default.
- W97376612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1235911" @default.
- W97376612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6603892" @default.
- W97376612 hasPublicationYear "1983" @default.
- W97376612 type Work @default.
- W97376612 sameAs 97376612 @default.
- W97376612 citedByCount "2" @default.
- W97376612 crossrefType "journal-article" @default.
- W97376612 hasAuthorship W97376612A5019952675 @default.
- W97376612 hasConcept C118487528 @default.
- W97376612 hasConcept C126322002 @default.
- W97376612 hasConcept C134018914 @default.
- W97376612 hasConcept C144594695 @default.
- W97376612 hasConcept C185592680 @default.
- W97376612 hasConcept C203014093 @default.
- W97376612 hasConcept C2777292125 @default.
- W97376612 hasConcept C2778261982 @default.
- W97376612 hasConcept C2778382381 @default.
- W97376612 hasConcept C2780077467 @default.
- W97376612 hasConcept C2780434524 @default.
- W97376612 hasConcept C2992139802 @default.
- W97376612 hasConcept C3020486325 @default.
- W97376612 hasConcept C54173615 @default.
- W97376612 hasConcept C71924100 @default.
- W97376612 hasConcept C77171857 @default.
- W97376612 hasConcept C89560881 @default.
- W97376612 hasConceptScore W97376612C118487528 @default.
- W97376612 hasConceptScore W97376612C126322002 @default.
- W97376612 hasConceptScore W97376612C134018914 @default.
- W97376612 hasConceptScore W97376612C144594695 @default.
- W97376612 hasConceptScore W97376612C185592680 @default.
- W97376612 hasConceptScore W97376612C203014093 @default.
- W97376612 hasConceptScore W97376612C2777292125 @default.
- W97376612 hasConceptScore W97376612C2778261982 @default.
- W97376612 hasConceptScore W97376612C2778382381 @default.
- W97376612 hasConceptScore W97376612C2780077467 @default.
- W97376612 hasConceptScore W97376612C2780434524 @default.
- W97376612 hasConceptScore W97376612C2992139802 @default.
- W97376612 hasConceptScore W97376612C3020486325 @default.
- W97376612 hasConceptScore W97376612C54173615 @default.
- W97376612 hasConceptScore W97376612C71924100 @default.
- W97376612 hasConceptScore W97376612C77171857 @default.
- W97376612 hasConceptScore W97376612C89560881 @default.
- W97376612 hasIssue "2" @default.
- W97376612 hasLocation W973766121 @default.
- W97376612 hasOpenAccess W97376612 @default.
- W97376612 hasPrimaryLocation W973766121 @default.
- W97376612 hasRelatedWork W1971056157 @default.
- W97376612 hasRelatedWork W1983969823 @default.
- W97376612 hasRelatedWork W2016248762 @default.
- W97376612 hasRelatedWork W2287255007 @default.
- W97376612 hasRelatedWork W2295105222 @default.
- W97376612 hasRelatedWork W2319964132 @default.
- W97376612 hasRelatedWork W2357452117 @default.
- W97376612 hasRelatedWork W2393210194 @default.
- W97376612 hasRelatedWork W2417434928 @default.
- W97376612 hasRelatedWork W97376612 @default.
- W97376612 hasVolume "47" @default.
- W97376612 isParatext "false" @default.
- W97376612 isRetracted "false" @default.
- W97376612 magId "97376612" @default.
- W97376612 workType "article" @default.