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- W97403023 abstract "Obesity is a harmful and costly condition which continues to increase in prevalence. Co-morbidities accompanying this disease now include brain-based disorders that impact cognition and mood. Illumina BeadChip Arrays performed on brains from high-fat diet (HFD) and low-fat diet (LFD) fed mice revealed a 60-fold increase in prolactin mRNA expression in HFD mice. Real time PCR confirmed this increase as 1643-fold. Since central DA inhibits prolactin secretion, the DA degradation enzyme catechol-O-methyl transferase (COMT) was examined by real time PCR and showed a 1000-fold increase HFD mice brains as compared to LFD mice brains. Potentially linked to brain-based DA loss are behavioral changes such as anhedonia and depression. Saccharin preference testing showed that HFD mice as compared to LFD mice exhibited saccharin aversion (25% vs 75% of total fluid consumption). In support, HFD mice also demonstrated a 2.3-fold decrease in burrowing as compared to LFD mice. To probe the mechanism of these behavioral changes db/db mice (which lack a functional leptin receptor) were examined and found to have a preference for saccharin (93% vs 27% of total fluid consumption) and increased burrowing (4.5-fold) when compared to HFD mice. Finally, brain based leptin mRNA expression was increased 3-fold in HFD mice when compared to LFD mice. Taken together these findings suggest that leptin regulates reward motivation in HFD mice by impacting COMT expression and DA degradation." @default.
- W97403023 created "2016-06-24" @default.
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- W97403023 date "2009-04-01" @default.
- W97403023 modified "2023-10-16" @default.
- W97403023 title "High fat diet alters expression of catechol‐O‐methyltransferase in the brains of mice and decreases motivation to obtain reward" @default.
- W97403023 doi "https://doi.org/10.1096/fasebj.23.1_supplement.lb523" @default.
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