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- W974182114 abstract "Receptor PTK Flt1 is a member of the CSFIR/Kit/PDGFR super-gene family. The endothelial cell-specific vascular endothelial growth factor specifically binds Flt1 with high affinity and mediates a signal for calcium mobilization in Xenopus oocytes overexpressing Flt1. Flt1 shows the typical structure of receptor-type PTK, with a ligand-binding extracellular domain, a transmembrane domain and an intracellular kinase domain. The ligand-binding domain could form seven Ig-like units with disulphide bonds. The two most C-terminal Ig-like domains are not found in CSFIR/Kit/PDGFR. Flt1 contains an insert in the kinase domain similar to that of CSFIR/Kit/PDGFR. However, the YXXM motif within the kinase insert region of the latter three receptors, which is considered to be a PI-3-Kinase binding site, is not conserved in Flt1. Flt1 has been sequenced from human (placenta) and rat (lung). In normal rats, the FLT1 mRNA is expressed in most tissues at low levels. The amount is relatively high in placenta, lung, and brain when compared to that of other tissues." @default.
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- W974182114 date "1995-01-01" @default.
- W974182114 modified "2023-09-30" @default.
- W974182114 title "Flt1" @default.
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- W974182114 doi "https://doi.org/10.1016/b978-012324719-3/50181-3" @default.
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