FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W97454891> ?p ?o ?g. }

• W97454891 endingPage "242" @default.
• W97454891 startingPage "229" @default.
• W97454891 abstract "Hapten-specific B-cell tolerance may be induced by nonimmunogenic hapten derivatives of carboxylmethylcellulose or methylcellulose (MC) in adult, neonatal, or irradiated fetal liver reconstituted mice. Such tolerance was shown to occur independent of T cells, and a receptor blockade has been ruled out as a causative mechanism. Oxidation and subsequent reduction of the vicinal hydroxyl groups of both carriers significantly reduces their tolerogenic potential in adult mice, yet their hapten derivatives remain nonimmunogenic. Such chemical modification of the carrier does not affect the molecular weight and not only does not reduce the binding avidity but increases it for either free antibody- or antigen-binding cells. We have examined the ability of the immature immune system to functionally discriminate between the nominal and the chemically modified hapten conjugate. Like adult mice, the immunologically immature animals were invariably capable of distinguishing between the tolerogenic and the nontolerogenic carrier. Mice treated during ontogenic development with 2,4-dinitrophenyl (DNP)-MC were found to be hapten specifically tolerant when challenged at 4 weeks of age with the TI-2 antigen DNP-Ficoll (F) but not when challenged with the polyclonal activator lipopolysaccharide (LPS) or the TI-1 antigen DNP-Brucella. Moreover, neonatal mice treated for 8 weeks with 2,4,6-trinitrophenyl-ovalbumin (TNP-OVA) were hapten specifically tolerant when challenged with TNP-OVA or the TI-1 antigen TNP-LPS but responded to a challenge with the TI-2 antigen TNP-F. These data suggest that B-cell tolerance in adult as well as in immunologically immature mice is not only carrier dependent but, in addition, that the carrier selects the B subpopulation to be rendered unresponsive. The most popular version of the clonal abortion hypothesis puts no constraints upon the nature of the antigen as long as the B cell is ontogenically “predisposed” toward being rendered unresponsive upon contact with a ligand of sufficiently high binding avidity. Our data are at variance with this prediction." @default.
• W97454891 created "2016-06-24" @default.
• W97454891 creator A5002518779 @default.
• W97454891 creator A5013992791 @default.
• W97454891 creator A5037426077 @default.
• W97454891 creator A5063340952 @default.
• W97454891 date "1983-10-01" @default.
• W97454891 modified "2023-09-25" @default.
• W97454891 title "Tolerance induction during ontogeny" @default.
• W97454891 cites W1481687430 @default.
• W97454891 cites W1487997993 @default.
• W97454891 cites W1530935295 @default.
• W97454891 cites W1592183697 @default.
• W97454891 cites W1606203579 @default.
• W97454891 cites W1652473508 @default.
• W97454891 cites W1691896390 @default.
• W97454891 cites W1792793557 @default.
• W97454891 cites W1877845887 @default.
• W97454891 cites W1918956394 @default.
• W97454891 cites W1975649472 @default.
• W97454891 cites W2005770085 @default.
• W97454891 cites W2052733766 @default.
• W97454891 cites W2081181868 @default.
• W97454891 cites W2083267402 @default.
• W97454891 cites W2102696650 @default.
• W97454891 cites W2112970530 @default.
• W97454891 cites W2151297336 @default.
• W97454891 cites W2162523413 @default.
• W97454891 cites W247549074 @default.
• W97454891 doi "https://doi.org/10.1016/0008-8749(83)90231-9" @default.
• W97454891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6196124" @default.
• W97454891 hasPublicationYear "1983" @default.
• W97454891 type Work @default.
• W97454891 sameAs 97454891 @default.
• W97454891 citedByCount "5" @default.
• W97454891 crossrefType "journal-article" @default.
• W97454891 hasAuthorship W97454891A5002518779 @default.
• W97454891 hasAuthorship W97454891A5013992791 @default.
• W97454891 hasAuthorship W97454891A5037426077 @default.
• W97454891 hasAuthorship W97454891A5063340952 @default.
• W97454891 hasConcept C134018914 @default.
• W97454891 hasConcept C147483822 @default.
• W97454891 hasConcept C153911025 @default.
• W97454891 hasConcept C159654299 @default.
• W97454891 hasConcept C203014093 @default.
• W97454891 hasConcept C2776946954 @default.
• W97454891 hasConcept C2777702733 @default.
• W97454891 hasConcept C2778754761 @default.
• W97454891 hasConcept C29144244 @default.
• W97454891 hasConcept C37291498 @default.
• W97454891 hasConcept C86803240 @default.
• W97454891 hasConcept C8891405 @default.
• W97454891 hasConceptScore W97454891C134018914 @default.
• W97454891 hasConceptScore W97454891C147483822 @default.
• W97454891 hasConceptScore W97454891C153911025 @default.
• W97454891 hasConceptScore W97454891C159654299 @default.
• W97454891 hasConceptScore W97454891C203014093 @default.
• W97454891 hasConceptScore W97454891C2776946954 @default.
• W97454891 hasConceptScore W97454891C2777702733 @default.
• W97454891 hasConceptScore W97454891C2778754761 @default.
• W97454891 hasConceptScore W97454891C29144244 @default.
• W97454891 hasConceptScore W97454891C37291498 @default.
• W97454891 hasConceptScore W97454891C86803240 @default.
• W97454891 hasConceptScore W97454891C8891405 @default.
• W97454891 hasIssue "2" @default.
• W97454891 hasLocation W974548911 @default.
• W97454891 hasLocation W974548912 @default.
• W97454891 hasOpenAccess W97454891 @default.
• W97454891 hasPrimaryLocation W974548911 @default.
• W97454891 hasRelatedWork W1972479046 @default.
• W97454891 hasRelatedWork W2011183043 @default.
• W97454891 hasRelatedWork W2017826569 @default.
• W97454891 hasRelatedWork W2033977323 @default.
• W97454891 hasRelatedWork W2049866354 @default.
• W97454891 hasRelatedWork W2077397102 @default.
• W97454891 hasRelatedWork W2411451838 @default.
• W97454891 hasRelatedWork W402048087 @default.
• W97454891 hasRelatedWork W70067030 @default.
• W97454891 hasRelatedWork W97454891 @default.
• W97454891 hasVolume "81" @default.
• W97454891 isParatext "false" @default.
• W97454891 isRetracted "false" @default.
• W97454891 magId "97454891" @default.
• W97454891 workType "article" @default.