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- W97471973 abstract "This chapter discusses the comparative aspects of hepatic monooxygenase induction in rat and rainbow trout by several polychlorinated biphenyl (PCB) isomers. Because of the widespread distribution of PCBs in the ecosphere including fresh and marine waters, the study described in the chapter investigated the effects of (1) two commercial mixtures of PCBs, namely, Aroclors 1254 and 1242, and (2) two pure non-coplanar PCB isomers and one pure coplanar isomer on the inducibility of rainbow trout hepatic cytochrome(s) P-450 activity. The hepatic cytochrome P-450 system of this strain of fish has proven refractive to induction by phenobarbitone-like agents. From the study, it was found that rodent and trout hepatic monooxygenation activities were induced more with the commercial PCB mixtures than with the individual isomers studied. The finding of chlorinated dioxins and dibenzofurans in these mixtures has been used to explain their potent inductive effects, especially on the cytochrome P-448 system." @default.
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- W97471973 date "1980-01-01" @default.
- W97471973 modified "2023-09-23" @default.
- W97471973 title "COMPARATIVE ASPECTS OF HEPATIC MONOOXYGENASE INDUCTION IN RAT AND RAINBOW TROUT BY SEVERAL PCB ISOMERS" @default.
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- W97471973 doi "https://doi.org/10.1016/b978-0-12-187702-6.50042-6" @default.
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