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- W974721157 abstract "This chapter discusses studies that focus on antiviral and antitumor chemotherapy with the interferon system. A tissue culture system for the production of mouse interferon of high titer was described. It involved the use of a virus-transformed 3T3 cell lines stimulated by Newcastle disease virus. Titers of 30,000 to 40,000 reference units/ml were regularly obtained. By dialysis concentration 10 times this titer could be achieved. Possible realistic evaluation of interferon therapy could be made using the mouse as a model. The interferon system was demonstrated to be effective prophylactically and in some cases therapeutically against a number of viruses in animals. Interferon itself was effective prophylactically and marginally effective therapeutically versus experimental rabies in rabbits and mice. Tilorone and poly rl:rC were found useful prophylactically against tick-borne encephalititis in mice. Foot and mouth disease in mice and in tissue culture was sensitive to the interferon system. In mice with West Nile virus, the protective prophylactic and therapeutic effect of poly rl:rC was ascribed to an action of interferon on the affected brain rather than just to the suppression of viremia. Mice that were too young to be immunologically competent were still protected against pseudorabies virus by statolon." @default.
- W974721157 created "2016-06-24" @default.
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- W974721157 date "1973-01-01" @default.
- W974721157 modified "2023-09-25" @default.
- W974721157 title "Chapter 16. Antiviral and Antitumor Chemotherapy with the Interferon System" @default.
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- W974721157 doi "https://doi.org/10.1016/s0065-7743(08)61244-0" @default.
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