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• W97473470 endingPage "649" @default.
• W97473470 startingPage "643" @default.
• W97473470 abstract "The effect of activation of the alpha-subunit(s) of the stimulatory guanine-nucleotide-binding protein, Gs, on levels of this polypeptide(s) associated with the plasma membrane of L6 skeletal myoblasts was ascertained. Incubation of these cells with cholera toxin led to a time- and concentration-dependent ‘down-regulation’ of both 44 and 42 kDa forms of Gs alpha as assessed by immunoblotting with an anti-peptide antiserum (CS1) able to identify the extreme C-terminus of Gs. The effect of cholera toxin was specific for Gs; levels of Gi alpha in membranes of cholera toxin-treated cells were not different from untreated cells. Down-regulation of Gs was absolutely dependent upon prior ADP-ribosylation, and hence activation of Gs and was not mimicked by other agents which elevate intracellular levels of cyclic AMP. Pretreatment with pertussis toxin, which catalyses ADP-ribosylation of Gi but not of Gs, did not down-regulate either Gi or Gs, demonstrating that covalent modification by ADP-ribosylation is alone not a signal for removal of G-proteins from the plasma membrane." @default.
• W97473470 created "2016-06-24" @default.
• W97473470 creator A5018415215 @default.
• W97473470 creator A5027660695 @default.
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• W97473470 date "1989-09-01" @default.
• W97473470 modified "2023-10-12" @default.
• W97473470 title "Cholera toxin treatment produces down-regulation of the <i>α</i>-subunit of the stimulatory guanine-nucleotide-binding protein (Gs)" @default.
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• W97473470 doi "https://doi.org/10.1042/bj2620643" @default.
• W97473470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1133316" @default.
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• W97473470 hasPublicationYear "1989" @default.
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