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• W97475057 abstract "Research Article1 September 1995free access Phosphorylation in halobacterial signal transduction. J. Rudolph J. Rudolph Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author N. Tolliday N. Tolliday Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author C. Schmitt C. Schmitt Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author S. C. Schuster S. C. Schuster Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author D. Oesterhelt D. Oesterhelt Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author J. Rudolph J. Rudolph Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author N. Tolliday N. Tolliday Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author C. Schmitt C. Schmitt Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author S. C. Schuster S. C. Schuster Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author D. Oesterhelt D. Oesterhelt Max Planck Institute for Biochemistry, Martinsried, Germany. Search for more papers by this author Author Information J. Rudolph1, N. Tolliday1, C. Schmitt1, S. C. Schuster1 and D. Oesterhelt1 1Max Planck Institute for Biochemistry, Martinsried, Germany. The EMBO Journal (1995)14:4249-4257https://doi.org/10.1002/j.1460-2075.1995.tb00099.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Regulated phosphorylation of proteins has been shown to be a hallmark of signal transduction mechanisms in both Eubacteria and Eukarya. Here we demonstrate that phosphorylation and dephosphorylation are also the underlying mechanism of chemo- and phototactic signal transduction in Archaea, the third branch of the living world. Cloning and sequencing of the region upstream of the cheA gene, known to be required for chemo- and phototaxis in Halobacterium salinarium, has identified cheY and cheB analogs which appear to form part of an operon which also includes cheA and the following open reading frame of 585 nucleotides. The CheY and CheB proteins have 31.3 and 37.5% sequence identity compared with the known signal transduction proteins CheY and CheB from Escherichia coli, respectively. The biochemical activities of both CheA and CheY were investigated following their expression in E.coli, isolation and renaturation. Wild-type CheA could be phosphorylated in a time-dependent manner in the presence of [gamma-32P]ATP and Mg2+, whereas the mutant CheA(H44Q) remained unlabeled. Phosphorylated CheA was dephosphorylated rapidly by the addition of wild-type CheY. The mutant CheY(D53A) had no effect on phosphorylated CheA. The mechanism of chemo- and phototactic signal transduction in the Archaeon H.salinarium, therefore, is similar to the two-component signaling system known from chemotaxis in the eubacterium E.coli. Previous ArticleNext Article Volume 14Issue 171 September 1995In this issue RelatedDetailsLoading ..." @default.
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• W97475057 date "1995-09-01" @default.
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• W97475057 title "Phosphorylation in halobacterial signal transduction." @default.
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• W97475057 doi "https://doi.org/10.1002/j.1460-2075.1995.tb00099.x" @default.
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