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- W97476494 abstract "Regulatory sequences or factors involved in the regulation of target genes of Drosophila homeodomain proteins are largely unknown. Here, we identify sequence elements that are involved in the function of the fushi tarazu (ftz) autoregulatory element AE, a direct in vivo target of the homeodomain protein ftz. A systematic deletion analysis of AE in transgenic embryos defines multiple elements that are redundantly involved in enhancer activity. Sequences juxtaposed to ftz binding sites are not strictly required for enhancer function. Several sequence motifs are conserved in other developmentally regulated genes of Drosophila melanogaster and in the AE homologue of Drosophila virilis. The D. virilis AE is functional in D. melanogaster. The sequence motifs identified here are candidate elements contributing to the target specificity of the homeodomain protein ftz." @default.
- W97476494 created "2016-06-24" @default.
- W97476494 creator A5025407591 @default.
- W97476494 creator A5066848145 @default.
- W97476494 date "1993-03-01" @default.
- W97476494 modified "2023-10-13" @default.
- W97476494 title "Analysis of a fushi tarazu autoregulatory element: multiple sequence elements contribute to enhancer activity." @default.
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- W97476494 doi "https://doi.org/10.1002/j.1460-2075.1993.tb05752.x" @default.
- W97476494 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/413312" @default.
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