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- W974966125 abstract "The circadian rhythm is driven by an endogenous biological clock that regulate many biochemical and physiological processes with a 24h periodicity. A conserved set of genes define a negative autoregulatory feedback loop that provides the core function in generating circadian rhythmicity on the level of transcription. In vertebrates, these genes include Per1, 2 and 3, as well as Cry1 and 2. In this study the nucleocytoplasmic transport of these circadian clock proteins was examined in Xenopus laevis oocytes and Hela cells. It turns out, that Per1 serves a dual function in the intracellular transport of other clock proteins; Per3 needs heterodimerisation with Per1 in order to gain access to the nucleus and, conversely, both Cry1 and Cry2 need heterodimerisation with Per1 in order to be exported from the nucleus. In order to test for the requirement of these activities in the context of the circadian rhythm, import- and export-defective Per1 mutants were stable transfected into NIH3T3 cells. By using semiquantitative RT-PCR and real time PCR it was shown that the mPer1 meditated export of mCry1 and mCry2 is essential for the circadian rhythmus in synchronized mouse fibroblasts." @default.
- W974966125 created "2016-06-24" @default.
- W974966125 creator A5022127707 @default.
- W974966125 date "2022-02-20" @default.
- W974966125 modified "2023-09-30" @default.
- W974966125 title "Analysen zum nukleozytoplasmatischen Transport von Regulatorproteinen des circadianen Rhythmus" @default.
- W974966125 doi "https://doi.org/10.53846/goediss-1389" @default.
- W974966125 hasPublicationYear "2022" @default.
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