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- W974999539 abstract "Exploring the affinity-pocket binding moiety of a 2-aminothiazole (S)-proline-amide-urea series of selective PI3Kα inhibitors using a parallel-synthesis approach led to the identification of a novel 4',5-bisthiazole sub-series. The synthesis and optimisation of both the affinity pocket and (S)-proline amide moieties within this 4',5-bisthiazole sub-series are described. From this work a number of analogues, including 14 (A66) and 24, were identified as potent and selective PI3Kα inhibitor in vitro tool compounds." @default.
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- W974999539 date "2015-09-01" @default.
- W974999539 modified "2023-10-01" @default.
- W974999539 title "Identification and optimisation of a 4′,5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors" @default.
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- W974999539 doi "https://doi.org/10.1016/j.bmcl.2015.06.078" @default.
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