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- W975090885 abstract "目的 探索用腺病毒作载体对脑胶质瘤进行基因治疗。方法 构建含ＣＭＶ启动子的ＨＳＶ－ｔｋ基因的重组腺病毒载体，将ＨＳＶ－ｔｋ基因转移至人脑胶质瘤细胞ＳＨＧ４４，用ＭＴＴ方法测定ＧＣＶ对肿瘤细胞的杀伤效果。结果 转染ＨＳＶ－ｔｋ基因的ＳＨＧ４４细胞以ＧＣＶ的敏感性增高８０倍，ＭＯＩ为１００时，５ｍｇ／Ｌ的ＧＣＶ能完全杀伤肿瘤细胞，并存在旁观者效应，一个转基因细胞能引起的１０倍的亲本细胞对ＧＣＶ敏感。结" @default.
- W975090885 created "2016-06-24" @default.
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- W975090885 date "1998-01-08" @default.
- W975090885 modified "2023-09-24" @default.
- W975090885 title "腺病毒介导的HSV-tk/GCV系统对人脑胶质瘤细胞的杀伤作用" @default.
- W975090885 hasPublicationYear "1998" @default.
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