Matches in SemOpenAlex for { <https://semopenalex.org/work/W975161444> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W975161444 endingPage "47.9" @default.
- W975161444 startingPage "47.9" @default.
- W975161444 abstract "Abstract Type 1 diabetes (T1D) is an autoimmune disease resulting from the complex interaction of multiple genetic and environmental factors. The nonobese diabetic (NOD) mouse has proven to be a useful model for investigating T1D susceptibility loci and their immunological effects upon disease progression. We have mapped a NOD diabetes susceptibility locus, termed Idd11, on chromosome 4 (Chr4). A panel of congenic NOD mouse strains, harbouring different C57BL/6 (B6, a diabetes-resistant strain)-derived intervals for Chr4, localized Idd11 to an ~7kb interval. Comparison of diabetes incidence and crossover breakpoints for these strains suggested that a haplotype for this locus underlies T1D susceptibility in NOD mice. Based on publicly available databases, the Idd11 haplotype is located within a predicted gene of unknown function (AK005651). Genomic characterization of AK005651 reveals that this novel gene encodes multiple splice isoforms and open-reading frames, none of which has homology with known proteins. Preliminary expression analysis also indicates that AK005651 is differentially expressed in tissues relevant to T1D, with NOD mice demonstrating altered splicing and reduced expression compared to diabetes-resistant strains. Ongoing studies aim to determine the effect of Idd11 / AK005651 on T1D pathogenesis." @default.
- W975161444 created "2016-06-24" @default.
- W975161444 creator A5001135422 @default.
- W975161444 creator A5012563060 @default.
- W975161444 creator A5027183726 @default.
- W975161444 creator A5027432844 @default.
- W975161444 creator A5030622173 @default.
- W975161444 creator A5035028685 @default.
- W975161444 creator A5040126252 @default.
- W975161444 creator A5053112911 @default.
- W975161444 creator A5054704071 @default.
- W975161444 creator A5061005232 @default.
- W975161444 creator A5061764650 @default.
- W975161444 creator A5074353962 @default.
- W975161444 creator A5086094573 @default.
- W975161444 date "2011-04-01" @default.
- W975161444 modified "2023-09-26" @default.
- W975161444 title "Congenic mouse strains identify a novel gene for which allelic variation affects susceptibility to type 1 diabetes (47.9)" @default.
- W975161444 doi "https://doi.org/10.4049/jimmunol.186.supp.47.9" @default.
- W975161444 hasPublicationYear "2011" @default.
- W975161444 type Work @default.
- W975161444 sameAs 975161444 @default.
- W975161444 citedByCount "0" @default.
- W975161444 crossrefType "journal-article" @default.
- W975161444 hasAuthorship W975161444A5001135422 @default.
- W975161444 hasAuthorship W975161444A5012563060 @default.
- W975161444 hasAuthorship W975161444A5027183726 @default.
- W975161444 hasAuthorship W975161444A5027432844 @default.
- W975161444 hasAuthorship W975161444A5030622173 @default.
- W975161444 hasAuthorship W975161444A5035028685 @default.
- W975161444 hasAuthorship W975161444A5040126252 @default.
- W975161444 hasAuthorship W975161444A5053112911 @default.
- W975161444 hasAuthorship W975161444A5054704071 @default.
- W975161444 hasAuthorship W975161444A5061005232 @default.
- W975161444 hasAuthorship W975161444A5061764650 @default.
- W975161444 hasAuthorship W975161444A5074353962 @default.
- W975161444 hasAuthorship W975161444A5086094573 @default.
- W975161444 hasConcept C104317684 @default.
- W975161444 hasConcept C180754005 @default.
- W975161444 hasConcept C197754878 @default.
- W975161444 hasConcept C2778013207 @default.
- W975161444 hasConcept C54355233 @default.
- W975161444 hasConcept C55851684 @default.
- W975161444 hasConcept C84597430 @default.
- W975161444 hasConcept C84951073 @default.
- W975161444 hasConcept C86803240 @default.
- W975161444 hasConceptScore W975161444C104317684 @default.
- W975161444 hasConceptScore W975161444C180754005 @default.
- W975161444 hasConceptScore W975161444C197754878 @default.
- W975161444 hasConceptScore W975161444C2778013207 @default.
- W975161444 hasConceptScore W975161444C54355233 @default.
- W975161444 hasConceptScore W975161444C55851684 @default.
- W975161444 hasConceptScore W975161444C84597430 @default.
- W975161444 hasConceptScore W975161444C84951073 @default.
- W975161444 hasConceptScore W975161444C86803240 @default.
- W975161444 hasIssue "1_Supplement" @default.
- W975161444 hasLocation W9751614441 @default.
- W975161444 hasOpenAccess W975161444 @default.
- W975161444 hasPrimaryLocation W9751614441 @default.
- W975161444 hasRelatedWork W1551477413 @default.
- W975161444 hasRelatedWork W1981788945 @default.
- W975161444 hasRelatedWork W1982749768 @default.
- W975161444 hasRelatedWork W2015602180 @default.
- W975161444 hasRelatedWork W2044114405 @default.
- W975161444 hasRelatedWork W2057739827 @default.
- W975161444 hasRelatedWork W2069288373 @default.
- W975161444 hasRelatedWork W2087118228 @default.
- W975161444 hasRelatedWork W2155294402 @default.
- W975161444 hasRelatedWork W4234789023 @default.
- W975161444 hasVolume "186" @default.
- W975161444 isParatext "false" @default.
- W975161444 isRetracted "false" @default.
- W975161444 magId "975161444" @default.
- W975161444 workType "article" @default.