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- W975203906 abstract "目的研究生长激素（Growth hormone,GH）对大鼠心肌缺血/再灌注（ischemia reperfusion,I/R）后心肌细胞凋亡及相关基因Caspase-3、Cleaved caspase-3蛋白表达的影响。方法24只大鼠随机分为三组,假手术组（sham-operated group,n=8,仅手术24h）、心肌缺血/再灌注（I/R）组（n=8）、GH组（n=8）,后两组均缺血30min,再灌注24h,GH组于建立模型前7d每天给予人重组生长激素（reconbination human growth hormone,rhGH）针剂皮下注射（1U/kg体质量）,其他二组等量生理盐水注射。以TUNEL法检测心肌细胞凋亡情况,DAB免疫组化法检测心肌细胞Caspase-3、Cleaved caspase-3蛋白表达并进行心肌组织病理学检查。结果大鼠心肌I/R24h后心肌细胞凋亡指数明显上升（对照于假手术组,P〈0.05）,心肌细胞Caspase-3、Cleaved caspase-3蛋白表达呈阳性染色指数明显升高（P〈0.05）,心肌病理检查见心肌缺血区呈大小不一的坏死灶,缺血心肌间有炎症细胞浸润,心肌排列不整齐（HE染色）,而GH组心肌细胞凋亡率及心肌细胞Caspase-3、Cleaved caspase-3蛋白表达呈阳性染色指数明显好于I/R组（P〈0.05）,心肌细胞炎症细胞也明显减少,坏死灶也少于I/R组。结论GH可以减少心肌I/R后心肌细胞凋亡及细胞Caspase-3、Cleaved caspase-3染色阳性指数,说明GH对I/R后的心肌具有保护作用。" @default.
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- W975203906 date "2008-01-01" @default.
- W975203906 modified "2023-09-23" @default.
- W975203906 title "生长激素对大鼠心肌缺血/再灌注后心肌细胞凋亡及凋亡相关基因Caspase-3 Cleaved caspase-3蛋白表达的影响" @default.
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