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- W975228462 abstract "Publisher Summary This chapter focuses on a still-emerging area of study on nicotinic acetylcholine receptor, that of the relationship between receptor occupation by ligands and the physiologic or pharmacologic response. It is the linkage between occupation and response, which confers the unique transduction capacities to receptor molecules as well as dictates their pharmacologic specificity for agonists, partial agonists, and antagonists. Since agonists can induce both an open channel and a desensitized state of the receptor and combinations of ligands can alter the character of the open channel state, analysis of the response itself is complex. It is evident that the receptor can exist in various states, which differ in their affinity for ligands, conductance behavior, and conformation. Hence, the analysis include a comparison of ligand binding functions with functions of receptor state. With the knowledge of receptor structure and the understanding of its channel properties in biophysical terms, both developing to a relatively advanced stage, it is becoming possible to relate functional behavior to molecular details on structure." @default.
- W975228462 created "2016-06-24" @default.
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- W975228462 creator A5065609114 @default.
- W975228462 date "1983-01-01" @default.
- W975228462 modified "2023-10-13" @default.
- W975228462 title "The Linkage between Ligand Occupation and Response of the Nicotinic Acetylcholine Receptor" @default.
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