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• W9755753 abstract "Background: To study the dose-dependent effects of histamine on capillary permeability in human skin, using the microinjection technique. Patients and methods: Eight healthy volunteers (2 w, 6 m; mean age 33 years) were included in the study. On two separate occasions, glass microcannulas with a tip diameter of 7 to 9 mum were inserted into the subepidermal layer of the skin at the distal medial tibia surface of each lower limb with a micromanipulator. In each subject, 0.5 mul of 3 different concentrations of histamine solution (0.1™, 0.01™ and 0.001™) were injected and compared to the solvent (0.9% NaCl). Transcapillary diffusion of intraveneously administered Na-fluorescein was assessed simultaneously using two fluorescence videomicroscopy systems. Off-line video densitometry was performed in an area of 0.56 mm 2 around the injection sites and fluorescence light intensities were measured in arbitrary units (AU) at 10, 30, 60, 120 and 600 s after dye appearance. Results: Compared to the solvent histamine microinjections resulted in a dose-dependent increase of mean fluorescence light intensities (FLI). Whereas mean FLI for the 0.001™ histamine injection was only significantly elevated 10 min after dye appearence (p < 0.05) an increase of mean FLI was already observed 10 s after dye appearence following the 0.1™ histamine injection (p < 0.05), which was more pronounced at later time points (p < 0.001). Mean FLI’s for the 0.01™ histamine solution were in between and resulted in significantly elevated values 1 min to 10 min after dye appearence (p < 0.05). Conclusions: We conclude that the microinjection technique together with fluorescence videomicroscopy described previously [6] is able to document a dose-dependent effect of histamine microinjections on skin capillary permeability. The technique may facilitate to determine appropriate dosages not only of histamine in order to test the effect of antagonists on human skin capillary permeability." @default.
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• W9755753 date "1999-05-01" @default.
• W9755753 modified "2023-09-23" @default.
• W9755753 title "Dosisabhängiger Anstieg der transkapillären Diffusion von Natriumfluoreszein nach Histamin-Mikroinjektionen" @default.
• W9755753 doi "https://doi.org/10.1024/0301-1526.28.2.79" @default.
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