FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W97563417> ?p ?o ?g. }

• W97563417 abstract "Publisher Summary In mammalian cells, the response to external signals can be propagated to the nucleus by several basic mechanisms. In one case, molecules such as hormones, neurotransmitters, and growth factors activate cell surface receptors leading to changes in second messengers, which eventually influence the level and/or activity of transcription factors. One well-characterized transcription factor is the cyclic AMP response element-binding protein (CREB), which recognizes cAMP response elements (CREs) in the promotor or enhancer regions of inducible genes. Another mechanism to transducer an external signal to nucleus is via steroid hormone receptors. The binding of these hormones to their receptors causes a conformational change of the proteins, which allows them to recognize hormone response elements (HREs) in the DNA sequence of inducible genes. This chapter explains these mechanisms through model gene tyrosine aminotransferase (TAT), a gluconeogenic enzyme switched on in the parenchymal cells of the liver shortly after birth. The chapter explores enhancer elements in the gluconeogenic enzyme gene TAT through genetic and molecular approaches. It describes a set of transcription factors that govern its tissue-specific expression and the hormonal regulation of the gene. Transgenic experiments explained in this chapter confirm in vivo requirement for specific enhancer elements for perinatal activation of TAT gene. The knockout experiments have revealed that unique enhancer sequences such as a CRE or a GRE are responsive to more than one transcription factor." @default.
• W97563417 created "2016-06-24" @default.
• W97563417 creator A5022907334 @default.
• W97563417 creator A5026438561 @default.
• W97563417 creator A5052790628 @default.
• W97563417 creator A5061234954 @default.
• W97563417 creator A5066794430 @default.
• W97563417 creator A5068228886 @default.
• W97563417 creator A5076889486 @default.
• W97563417 creator A5091438820 @default.
• W97563417 date "1995-01-01" @default.
• W97563417 modified "2023-09-27" @default.
• W97563417 title "Molecular Genetic Analysis of cAMP and Glucocorticoid Signaling in Development" @default.
• W97563417 cites W1494125107 @default.
• W97563417 cites W1496459044 @default.
• W97563417 cites W1785366854 @default.
• W97563417 cites W1791967303 @default.
• W97563417 cites W1867560451 @default.
• W97563417 cites W1966794733 @default.
• W97563417 cites W1972336344 @default.
• W97563417 cites W1982905517 @default.
• W97563417 cites W1985605578 @default.
• W97563417 cites W1988256844 @default.
• W97563417 cites W1996339709 @default.
• W97563417 cites W1999270780 @default.
• W97563417 cites W2000024512 @default.
• W97563417 cites W2005393972 @default.
• W97563417 cites W2021334674 @default.
• W97563417 cites W2028242823 @default.
• W97563417 cites W2032020317 @default.
• W97563417 cites W2032642518 @default.
• W97563417 cites W2052059711 @default.
• W97563417 cites W2055654988 @default.
• W97563417 cites W2058486930 @default.
• W97563417 cites W2060903877 @default.
• W97563417 cites W2074463981 @default.
• W97563417 cites W2081704409 @default.
• W97563417 cites W2104360623 @default.
• W97563417 cites W2157589212 @default.
• W97563417 cites W2259495534 @default.
• W97563417 doi "https://doi.org/10.1016/b978-0-12-571150-0.50009-3" @default.
• W97563417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7740187" @default.
• W97563417 hasPublicationYear "1995" @default.
• W97563417 type Work @default.
• W97563417 sameAs 97563417 @default.
• W97563417 citedByCount "0" @default.
• W97563417 crossrefType "book-chapter" @default.
• W97563417 hasAuthorship W97563417A5022907334 @default.
• W97563417 hasAuthorship W97563417A5026438561 @default.
• W97563417 hasAuthorship W97563417A5052790628 @default.
• W97563417 hasAuthorship W97563417A5061234954 @default.
• W97563417 hasAuthorship W97563417A5066794430 @default.
• W97563417 hasAuthorship W97563417A5068228886 @default.
• W97563417 hasAuthorship W97563417A5076889486 @default.
• W97563417 hasAuthorship W97563417A5091438820 @default.
• W97563417 hasConcept C101762097 @default.
• W97563417 hasConcept C104317684 @default.
• W97563417 hasConcept C111936080 @default.
• W97563417 hasConcept C121608353 @default.
• W97563417 hasConcept C132154277 @default.
• W97563417 hasConcept C132376346 @default.
• W97563417 hasConcept C138885662 @default.
• W97563417 hasConcept C150194340 @default.
• W97563417 hasConcept C153911025 @default.
• W97563417 hasConcept C1629964 @default.
• W97563417 hasConcept C165864922 @default.
• W97563417 hasConcept C179926584 @default.
• W97563417 hasConcept C181199279 @default.
• W97563417 hasConcept C2776491826 @default.
• W97563417 hasConcept C2909511254 @default.
• W97563417 hasConcept C41895202 @default.
• W97563417 hasConcept C51445715 @default.
• W97563417 hasConcept C530470458 @default.
• W97563417 hasConcept C54355233 @default.
• W97563417 hasConcept C55493867 @default.
• W97563417 hasConcept C59493245 @default.
• W97563417 hasConcept C84606932 @default.
• W97563417 hasConcept C86339819 @default.
• W97563417 hasConcept C86803240 @default.
• W97563417 hasConcept C95444343 @default.
• W97563417 hasConceptScore W97563417C101762097 @default.
• W97563417 hasConceptScore W97563417C104317684 @default.
• W97563417 hasConceptScore W97563417C111936080 @default.
• W97563417 hasConceptScore W97563417C121608353 @default.
• W97563417 hasConceptScore W97563417C132154277 @default.
• W97563417 hasConceptScore W97563417C132376346 @default.
• W97563417 hasConceptScore W97563417C138885662 @default.
• W97563417 hasConceptScore W97563417C150194340 @default.
• W97563417 hasConceptScore W97563417C153911025 @default.
• W97563417 hasConceptScore W97563417C1629964 @default.
• W97563417 hasConceptScore W97563417C165864922 @default.
• W97563417 hasConceptScore W97563417C179926584 @default.
• W97563417 hasConceptScore W97563417C181199279 @default.
• W97563417 hasConceptScore W97563417C2776491826 @default.
• W97563417 hasConceptScore W97563417C2909511254 @default.
• W97563417 hasConceptScore W97563417C41895202 @default.
• W97563417 hasConceptScore W97563417C51445715 @default.
• W97563417 hasConceptScore W97563417C530470458 @default.
• W97563417 hasConceptScore W97563417C54355233 @default.
• W97563417 hasConceptScore W97563417C55493867 @default.

• next