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- W97574369 abstract "Magnetic drug targeting is a method of transporting drugs to specific locations within the human body. For this purpose superparamagnetic nanoparticles (MNP) are combined with chemotherapeutic agents, injected into the circulatory system and guided to a target site using an external magnetic field that acts on the MNP. In this study, we examined the properties of a colloidal MNP droplet that adheres to a vessel wall under the influence of a magnetic field. A mathematical model was developed which approximates the strength of the required magnetic field in correlation to a given blood velocity. The results were numerically calculated and indicate that nanoparticles can be held stationary in surface vessels with a magnetic field strength of about 0.1 T. The mathematical model was verified in an experimental setup by means of optical measurements, and the loss of colloid volume was determined as a function of time and fluid velocity. For a high targeting efficiency, a high magnetic field gradient is required in the targeted body compartment. Hence, we virtually designed, built and tested multiple coil configurations and investigated which of these geometries fulfilled our requirements best by applying optimization procedures. Prostate gland was the example of use. One coil array was placed within the urethra and another array inside the rectum and the profile and strength of the magnetic field was analyzed while varying the spatial parameters of the setup. The targeting efficiency could be increased by a factor of more than 40 purely by geometrical optimization." @default.
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- W97574369 date "2009-01-01" @default.
- W97574369 modified "2023-10-16" @default.
- W97574369 title "Optimization of magnetic drug targeting by mathematical modeling and simulation of magnetic fields" @default.
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- W97574369 doi "https://doi.org/10.1007/978-3-540-89208-3_554" @default.
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