Matches in SemOpenAlex for { <https://semopenalex.org/work/W975902945> ?p ?o ?g. }
- W975902945 endingPage "213" @default.
- W975902945 startingPage "199" @default.
- W975902945 abstract "The NOD mouse model of type 1A (immune-mediated) diabetes and genetic derivatives of this strain are probably the most extensively studied autoimmune animal models (1–4 ). NOD mice spontaneously develop insulitis. This is followed in the great majority of female mice by sufficient beta-cell destruction to result in overt diabetes and approximately 50% of male mice develop diabetes. Insulitis develops between 4 and 8 weeks and over a prolonged period of time increasing numbers of mice develop severe hyperglycemia. In addition, the mice develop sialitis and other autoimmune disorders, such as thyroiditis, retinitis, and autoimmune neuropathy, depending upon the genetic backgrounds (5–7 ). Multiple derivatives of the NOD model (congenic strains of mice with specific mutations and transgenes) are available from repositories at the Jackson Laboratories and Taconic and from individual investigators. There is no doubt that type 1A diabetes is the result of T cell-mediated destruction of beta cells with genetic mutations and therapies that eliminate (e.g., Rag and SCID mutations) T cells preventing disease and ability to transfer the disease with autoreactive T cells." @default.
- W975902945 created "2016-06-24" @default.
- W975902945 creator A5038398583 @default.
- W975902945 creator A5066716873 @default.
- W975902945 date "2010-11-25" @default.
- W975902945 modified "2023-09-24" @default.
- W975902945 title "Immunopathogenesis of the NOD Mouse" @default.
- W975902945 cites W1487672635 @default.
- W975902945 cites W1499727701 @default.
- W975902945 cites W1528584436 @default.
- W975902945 cites W1551102474 @default.
- W975902945 cites W1571208696 @default.
- W975902945 cites W1577058011 @default.
- W975902945 cites W1586126658 @default.
- W975902945 cites W1629285726 @default.
- W975902945 cites W1896577038 @default.
- W975902945 cites W1929437198 @default.
- W975902945 cites W1959582193 @default.
- W975902945 cites W1963770029 @default.
- W975902945 cites W1966454866 @default.
- W975902945 cites W1967517343 @default.
- W975902945 cites W1971885146 @default.
- W975902945 cites W1973485458 @default.
- W975902945 cites W1982761604 @default.
- W975902945 cites W1983509539 @default.
- W975902945 cites W1991294321 @default.
- W975902945 cites W1996012421 @default.
- W975902945 cites W1996611865 @default.
- W975902945 cites W1997452174 @default.
- W975902945 cites W1998412928 @default.
- W975902945 cites W1998531275 @default.
- W975902945 cites W2000943282 @default.
- W975902945 cites W2001882980 @default.
- W975902945 cites W2002424665 @default.
- W975902945 cites W2006324199 @default.
- W975902945 cites W2006554521 @default.
- W975902945 cites W2012962101 @default.
- W975902945 cites W2019060341 @default.
- W975902945 cites W2026468137 @default.
- W975902945 cites W2026579751 @default.
- W975902945 cites W2026675198 @default.
- W975902945 cites W2027507645 @default.
- W975902945 cites W2032218738 @default.
- W975902945 cites W2035655456 @default.
- W975902945 cites W2041637201 @default.
- W975902945 cites W2041828861 @default.
- W975902945 cites W2045188762 @default.
- W975902945 cites W2046579578 @default.
- W975902945 cites W2049478216 @default.
- W975902945 cites W2049740824 @default.
- W975902945 cites W2055979243 @default.
- W975902945 cites W2060351717 @default.
- W975902945 cites W2060529824 @default.
- W975902945 cites W2061106786 @default.
- W975902945 cites W2062451762 @default.
- W975902945 cites W2064671266 @default.
- W975902945 cites W2068248004 @default.
- W975902945 cites W2069778638 @default.
- W975902945 cites W2072946532 @default.
- W975902945 cites W2078567778 @default.
- W975902945 cites W2082137006 @default.
- W975902945 cites W2087171945 @default.
- W975902945 cites W2087704501 @default.
- W975902945 cites W2096251387 @default.
- W975902945 cites W2096633199 @default.
- W975902945 cites W2097811455 @default.
- W975902945 cites W2100331344 @default.
- W975902945 cites W2102617156 @default.
- W975902945 cites W2106287552 @default.
- W975902945 cites W2107144645 @default.
- W975902945 cites W2108163614 @default.
- W975902945 cites W2110949372 @default.
- W975902945 cites W2113799022 @default.
- W975902945 cites W2114631843 @default.
- W975902945 cites W2117113925 @default.
- W975902945 cites W2117644665 @default.
- W975902945 cites W2121789150 @default.
- W975902945 cites W2124488643 @default.
- W975902945 cites W2126274788 @default.
- W975902945 cites W2128277870 @default.
- W975902945 cites W2130737345 @default.
- W975902945 cites W2135280067 @default.
- W975902945 cites W2138705990 @default.
- W975902945 cites W2144164666 @default.
- W975902945 cites W2144512464 @default.
- W975902945 cites W2145720279 @default.
- W975902945 cites W2146664729 @default.
- W975902945 cites W2149451873 @default.
- W975902945 cites W2159305979 @default.
- W975902945 cites W2159796764 @default.
- W975902945 cites W2164799740 @default.
- W975902945 doi "https://doi.org/10.1007/978-1-60327-478-4_12" @default.
- W975902945 hasPublicationYear "2010" @default.
- W975902945 type Work @default.
- W975902945 sameAs 975902945 @default.
- W975902945 citedByCount "1" @default.
- W975902945 countsByYear W9759029452017 @default.
- W975902945 crossrefType "book-chapter" @default.