Matches in SemOpenAlex for { <https://semopenalex.org/work/W976176483> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W976176483 abstract "Objective We have provided evidence in former studies that cytokines (IL-8, TNF alpha, LBP, TGFβ) measured in blood correlate negatively with lung function in deltaF508 homozygous patients. GAP junction proteins might be of importance for the influx of blood cells into the lung. Our aim was to assess the relationship between connexin genotypes, cytokines (IL-8, TNF-α, LBP, TGFβ) in induced sputum and serum, and lung disease. Methods 36 patients homozygous for deltaF508 [median age 18 y, m/f 16/20, FEV 1 (%) 77] were examined. Sequence analysis was performed for GAP junction protein alpha 1 (GJA1/connexin 43) and gap junction protein alpha 4 (GJA4/connexin 37). Cytokines were assessed in serum and induced sputum (IS) by chemiluminesence (DPC Biermann, Bad Homburg, Germany) as well as leukocyte counts. Results 35 patients were sequenced. Whereas GJA1 showed only one rare heterozygous synonymous SNP (rs138386744) in one patient, four common SNPs were detected in GJA4. Two were synonymous changes, but the third variant (rs41266431) causes an amino acid substitution (GTA valine, ATA isoleucine) as well as the fourth SNP (rs1764391: CCC proline, TCC serine). For rs41266431 patients with homozygosity for the G variant had higher IL-8 levels (median: 13.3/8.0 pg/ml, p 30 years lung function (FEV1 41.3/84.83% predicted, p Conclusion For GJA4 the SNP at rs41266431 seems a promising candidate for a disease modifying gene." @default.
- W976176483 created "2016-06-24" @default.
- W976176483 creator A5003619183 @default.
- W976176483 creator A5010870367 @default.
- W976176483 creator A5039838472 @default.
- W976176483 creator A5046346741 @default.
- W976176483 creator A5046751901 @default.
- W976176483 creator A5046860509 @default.
- W976176483 creator A5052757728 @default.
- W976176483 creator A5074239342 @default.
- W976176483 creator A5081394859 @default.
- W976176483 creator A5084670904 @default.
- W976176483 date "2015-06-01" @default.
- W976176483 modified "2023-09-30" @default.
- W976176483 title "3 Connexin 37 and connexin 43 genotypes in correlation to cytokines in induced sputum and blood in cystic fibrosis (CF)" @default.
- W976176483 doi "https://doi.org/10.1016/s1569-1993(15)30180-6" @default.
- W976176483 hasPublicationYear "2015" @default.
- W976176483 type Work @default.
- W976176483 sameAs 976176483 @default.
- W976176483 citedByCount "0" @default.
- W976176483 crossrefType "journal-article" @default.
- W976176483 hasAuthorship W976176483A5003619183 @default.
- W976176483 hasAuthorship W976176483A5010870367 @default.
- W976176483 hasAuthorship W976176483A5039838472 @default.
- W976176483 hasAuthorship W976176483A5046346741 @default.
- W976176483 hasAuthorship W976176483A5046751901 @default.
- W976176483 hasAuthorship W976176483A5046860509 @default.
- W976176483 hasAuthorship W976176483A5052757728 @default.
- W976176483 hasAuthorship W976176483A5074239342 @default.
- W976176483 hasAuthorship W976176483A5081394859 @default.
- W976176483 hasAuthorship W976176483A5084670904 @default.
- W976176483 hasBestOaLocation W9761764831 @default.
- W976176483 hasConcept C104317684 @default.
- W976176483 hasConcept C126322002 @default.
- W976176483 hasConcept C135763542 @default.
- W976176483 hasConcept C139275648 @default.
- W976176483 hasConcept C142724271 @default.
- W976176483 hasConcept C153209595 @default.
- W976176483 hasConcept C158157758 @default.
- W976176483 hasConcept C203014093 @default.
- W976176483 hasConcept C2776301714 @default.
- W976176483 hasConcept C2776938444 @default.
- W976176483 hasConcept C2777573094 @default.
- W976176483 hasConcept C2780228694 @default.
- W976176483 hasConcept C2781069245 @default.
- W976176483 hasConcept C515207424 @default.
- W976176483 hasConcept C54355233 @default.
- W976176483 hasConcept C69991583 @default.
- W976176483 hasConcept C71924100 @default.
- W976176483 hasConcept C79879829 @default.
- W976176483 hasConcept C86803240 @default.
- W976176483 hasConceptScore W976176483C104317684 @default.
- W976176483 hasConceptScore W976176483C126322002 @default.
- W976176483 hasConceptScore W976176483C135763542 @default.
- W976176483 hasConceptScore W976176483C139275648 @default.
- W976176483 hasConceptScore W976176483C142724271 @default.
- W976176483 hasConceptScore W976176483C153209595 @default.
- W976176483 hasConceptScore W976176483C158157758 @default.
- W976176483 hasConceptScore W976176483C203014093 @default.
- W976176483 hasConceptScore W976176483C2776301714 @default.
- W976176483 hasConceptScore W976176483C2776938444 @default.
- W976176483 hasConceptScore W976176483C2777573094 @default.
- W976176483 hasConceptScore W976176483C2780228694 @default.
- W976176483 hasConceptScore W976176483C2781069245 @default.
- W976176483 hasConceptScore W976176483C515207424 @default.
- W976176483 hasConceptScore W976176483C54355233 @default.
- W976176483 hasConceptScore W976176483C69991583 @default.
- W976176483 hasConceptScore W976176483C71924100 @default.
- W976176483 hasConceptScore W976176483C79879829 @default.
- W976176483 hasConceptScore W976176483C86803240 @default.
- W976176483 hasLocation W9761764831 @default.
- W976176483 hasLocation W9761764832 @default.
- W976176483 hasOpenAccess W976176483 @default.
- W976176483 hasPrimaryLocation W9761764831 @default.
- W976176483 hasRelatedWork W1022695980 @default.
- W976176483 hasRelatedWork W1894893887 @default.
- W976176483 hasRelatedWork W1977517758 @default.
- W976176483 hasRelatedWork W2034508361 @default.
- W976176483 hasRelatedWork W2036201589 @default.
- W976176483 hasRelatedWork W2081584075 @default.
- W976176483 hasRelatedWork W2161077089 @default.
- W976176483 hasRelatedWork W2163845495 @default.
- W976176483 hasRelatedWork W2167711513 @default.
- W976176483 hasRelatedWork W2340111733 @default.
- W976176483 hasRelatedWork W2365001350 @default.
- W976176483 hasRelatedWork W2374492847 @default.
- W976176483 hasRelatedWork W2385384793 @default.
- W976176483 hasRelatedWork W2526441951 @default.
- W976176483 hasRelatedWork W2744357306 @default.
- W976176483 hasRelatedWork W2907658296 @default.
- W976176483 hasRelatedWork W2942399306 @default.
- W976176483 hasRelatedWork W3086179074 @default.
- W976176483 hasRelatedWork W3096495537 @default.
- W976176483 hasRelatedWork W2167026055 @default.
- W976176483 isParatext "false" @default.
- W976176483 isRetracted "false" @default.
- W976176483 magId "976176483" @default.
- W976176483 workType "article" @default.