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- W976262308 abstract "Vizsgaltuk a hialuronsav szintaz expressziojat (I.), valamint a sejt-sejt kozotti viztranszportban szerepet jatszo molekulak egyik csaladjanak, az aquaporinok expresszios mintazatat a human fogfejlődes kulonboző stadiumaiban (II.). Hasonloan az első ket pontban feltuntetett tudomanyos munkankhoz, a vitalmikroszkopos kiserleteink eredmenyeiből is, melyek soran tanulmanyoztuk a fogbel mikrocirkulaciojanak valtozasat kolonboző fogaszati anyagok aplikalasat kovetően, nemzetkozi, lektoralt folyoiratban tudomanyos publikacio kerult kozlesre (III.). Eredmenyeink es kovetkeztetesek: I.: A kulonboző fejlődesei stadiumokban a human fogcsirak sejtjeinek HAS expresszioja szoros osszefuggest mutatott az adott sejtek hialuronsav mintazataval, alatamasztva a hialuronsavnak a kulonboző fejlődesbiologiai folyamatokban jatszott kozponti szerepet a human fogfejlődes soran is. II.: Az altalunk vizsgalt es detektalt aquaporin izotipusoknak szerepe lehet a human fejlődő fogtelep strukturai korul kialakulo magasan hidratalt extracellularis matrix kialakitasaban. III.: A mindennapi fogorvosi gyakorlatban hasznalatos dentin sealerek hatasat vizsgalva a pulpalis erek eratmerőjere megallapithatjuk, hogy kulonboző kemiai csonkvedők hatasa jelentős es elterő mertekben hatnak a pulpalis kapillarisok eratmerőjere, melynek figyelembevetele ajanlatos a vegleges restauraciot megelőző fogaszati beavatkozasokkor. | We investigated the localization of hyaluronan synthases (HASs) in developing human dental structures (Ist research area) and also characterized the expression pattern of six different aquaporin isoforms (AQP1-5, AQP-9) in developing human and mouse tooth germs (IInd research area). Finally, we investigated the effect of locally blocked NO synthase on the internal diameter of rat pulpal arterioles under basal conditions and immediately after different dental bond material application by using vitalmicroscopic technique (IIIrd research area). The results of all of these 3 research areas has been summarized and published in 3 per reviewed international middle rank scientific paper. Results and conclusions: I research area: We provide evidences that HA synthesised locally by different dental cells and these results provide additional indirect support to the suggestion that HA may contribute both to the different processes of tooth development and dental hard tissue formation. II research area: The expression patterns of AQP isoforms on different developing dental structures reported in our study suggest that AQP water channels may play a role for ECM hydration during tooth development. III reserach area: Applying different dental bond material in vital microscopic conditions on rat incisors suggest that the local formation of NO may have a significant role in the acute vasodilation induced by bond material application and also in maintenance of basal pulpal arteriolar tone." @default.
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- W976262308 date "2007-01-01" @default.
- W976262308 modified "2023-09-30" @default.
- W976262308 title "Fog extracelluláris mátrixának és mikrocirculációjának vizsgálata = Examination of the extracellular matrix and the microcirculation of the tooth" @default.
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