FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W976724722> ?p ?o ?g. }

• W976724722 abstract "Final report for the California Air Resources Board and the California Environmental Protection Agency. Nitrogen dioxide (NO2) can enhance both early and late airway narrowing after inhaled antigen in allergic asthmatic subjects. We hypothesized that NO2 may also increase airway inflammation during the late response. Nitrogen dioxide has been shown to cause airway inflammation in healthy subjects without asthma. We also hypothesized that individuals with asthma may have increased non-allergic airway inflammation after exposure to NO2. To test these hypotheses, we designed two experiments with the following specific aims: Experiment 1) To determine the effect of a single exposure to NO2 on allergen-induced airway inflammation. Experiment Two: To determine the effect of NO2 exposure on non-allergic airway inflammation. Experiment One: 15 house dust mite (HDM)-sensitive asthmatic subjects were exposed for 3 hours to filtered air or 0.4 ppm NO2 followed immediately by inhalation of HDM allergen. Lung function was measured before and after each exposure and after allergen challenge, hourly for 6 hours. Sputum (airway lining fluid) was obtained at 6 hours and 26 hours after allergen challenge and assessed for inflammatory cells and biochemical markers of inflammation. There was no significant effect of NO2 exposure on early or late airway narrowing after HDM allergen for the group as a whole. However, three subjects did have substantially greater early airway narrowing with HDM allergen inhalation after NO2. A significant decrease in a type of inflammatory cell (eosinophils) was observed in sputum obtained 6 hours after NO2, but there was no significant NO2-related difference for any other measure of inflammation. These results suggest that in most asthmatic individuals a 3-hour exposure to a high ambient concentration of NO2 does not increase the late airway inflammatory response to inhaled allergen. There may, however, be a subset of allergic asthmatic individuals in whom NO2 exposure does increase early airway narrowing. Future research should be directed towards understanding the determinants of why some asthmatic individuals are more susceptible to NO2. Experiment Two: 10 asthmatic subjects were exposed for 3 hours to filtered air or 0.4 ppm NO2 followed by sputum sampling. Lung function was measured before and after each exposure. Sputum was obtained at 6 hours and 26 hours after exposure and assessed for inflammatory cells and biochemical markers of inflammation. There was no significant effect of NO2 exposure on lung function or any measures of inflammation in sputum. These results suggest that in mild asthmatic individuals a 3-hour exposure to a high ambient level of NO2 does not cause either airway narrowing or non-allergic airway inflammation." @default.
• W976724722 created "2016-06-24" @default.
• W976724722 creator A5004834064 @default.
• W976724722 date "2004-01-01" @default.
• W976724722 modified "2023-09-23" @default.
• W976724722 title "Effects of nitrogen dioxide on airway inflammation in allergic asthmatic subjects." @default.
• W976724722 cites W116999468 @default.
• W976724722 cites W1708591321 @default.
• W976724722 cites W1936415295 @default.
• W976724722 cites W1977518668 @default.
• W976724722 cites W1980806711 @default.
• W976724722 cites W1987879353 @default.
• W976724722 cites W1988619534 @default.
• W976724722 cites W1994101665 @default.
• W976724722 cites W1996295700 @default.
• W976724722 cites W1999535273 @default.
• W976724722 cites W2000889140 @default.
• W976724722 cites W2006046995 @default.
• W976724722 cites W2008801406 @default.
• W976724722 cites W2012433709 @default.
• W976724722 cites W2014602851 @default.
• W976724722 cites W2020653207 @default.
• W976724722 cites W2035779214 @default.
• W976724722 cites W2043187132 @default.
• W976724722 cites W2043466135 @default.
• W976724722 cites W2043686537 @default.
• W976724722 cites W2045827836 @default.
• W976724722 cites W2052498959 @default.
• W976724722 cites W2054788262 @default.
• W976724722 cites W2056098544 @default.
• W976724722 cites W2064677176 @default.
• W976724722 cites W2069421791 @default.
• W976724722 cites W2071016103 @default.
• W976724722 cites W2073431418 @default.
• W976724722 cites W2073737004 @default.
• W976724722 cites W2075339399 @default.
• W976724722 cites W2075818180 @default.
• W976724722 cites W2076659299 @default.
• W976724722 cites W2077274417 @default.
• W976724722 cites W2081887519 @default.
• W976724722 cites W2082556127 @default.
• W976724722 cites W2086948436 @default.
• W976724722 cites W2090154062 @default.
• W976724722 cites W2092953840 @default.
• W976724722 cites W2093395477 @default.
• W976724722 cites W2093421930 @default.
• W976724722 cites W2095023400 @default.
• W976724722 cites W2096246627 @default.
• W976724722 cites W2097810816 @default.
• W976724722 cites W2098092685 @default.
• W976724722 cites W2105225035 @default.
• W976724722 cites W2109249573 @default.
• W976724722 cites W2109797390 @default.
• W976724722 cites W2110133908 @default.
• W976724722 cites W2110260255 @default.
• W976724722 cites W2110953827 @default.
• W976724722 cites W2113371251 @default.
• W976724722 cites W2119531363 @default.
• W976724722 cites W2119783885 @default.
• W976724722 cites W2121464855 @default.
• W976724722 cites W2131555708 @default.
• W976724722 cites W2133360280 @default.
• W976724722 cites W2135432052 @default.
• W976724722 cites W2137610894 @default.
• W976724722 cites W2138367870 @default.
• W976724722 cites W2145349699 @default.
• W976724722 cites W2147764200 @default.
• W976724722 cites W2149409081 @default.
• W976724722 cites W2152508973 @default.
• W976724722 cites W2154279726 @default.
• W976724722 cites W2157043675 @default.
• W976724722 cites W2165672101 @default.
• W976724722 cites W2167001130 @default.
• W976724722 cites W2167999114 @default.
• W976724722 cites W2226765030 @default.
• W976724722 cites W2282062309 @default.
• W976724722 cites W2333379597 @default.
• W976724722 cites W2336431486 @default.
• W976724722 cites W2410998962 @default.
• W976724722 cites W2439029965 @default.
• W976724722 cites W2466614717 @default.
• W976724722 cites W2604596332 @default.
• W976724722 cites W56457521 @default.
• W976724722 hasPublicationYear "2004" @default.
• W976724722 type Work @default.
• W976724722 sameAs 976724722 @default.
• W976724722 citedByCount "0" @default.
• W976724722 crossrefType "journal-article" @default.
• W976724722 hasAuthorship W976724722A5004834064 @default.
• W976724722 hasConcept C105922876 @default.
• W976724722 hasConcept C142724271 @default.
• W976724722 hasConcept C178790620 @default.
• W976724722 hasConcept C185592680 @default.
• W976724722 hasConcept C203014093 @default.
• W976724722 hasConcept C207480886 @default.
• W976724722 hasConcept C2776042228 @default.
• W976724722 hasConcept C2776301714 @default.
• W976724722 hasConcept C2776914184 @default.
• W976724722 hasConcept C2776954882 @default.
• W976724722 hasConcept C2778166374 @default.

• next